INT77686

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.65
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
liver 1
brain 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
Endogenous opioid 2 98.20 Very High Very High Very High
alcohol 2 88.20 High High
opioid receptor 3 75.00 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 75 99.44 Very High Very High Very High
Metastasis 80 98.64 Very High Very High Very High
Colon Cancer 82 98.20 Very High Very High Very High
Alcohol Addiction 2 97.20 Very High Very High Very High
Sprains And Strains 3 94.60 High High
Fibrosis 5 60.76 Quite High
Chronic Renal Failure 64 57.08 Quite High
Increased Venous Pressure Under Development 1 56.16 Quite High
Renal Disease 23 50.72 Quite High
Disease 9 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DRI, direct renin inhibitor; ACE, angiotensin converting enzyme; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker
Transcription (DRI) of ACE
1) Confidence 0.65 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.22 Pain Relevance 0
In the first experiment, basal mRNA levels of mu- and delta-opioid receptors, and of opioid-degrading enzymes enkephalinase (neutral endopeptidase 24.11; NEP) and angiotensin-converting enzyme (ACE) in the brain regions of C57BL/6 and DBA/2 mice did not reveal genetically determined differences in these parameters between the two strains.
Spec (determined) Transcription (levels) of ACE in brain associated with delta opioid receptors, sprains and strains and opioid
2) Confidence 0.64 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.35 Pain Relevance 0.37
In contrast to ACE, ACE2 mRNA expression was lower in tumors compared to the surrounding liver at day 21 in control animals (P = 0.0011) (Table 2).


Transcription (expression) of ACE in liver associated with cancer
3) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.08 Pain Relevance 0

General Comments

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