INT77688

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Context Info
Confidence 0.53
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.01
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
lungs 4
brain 1
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
Endogenous opioid 2 98.20 Very High Very High Very High
alcohol 2 88.20 High High
Inflammation 28 85.12 High High
opioid receptor 3 75.00 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 352 98.84 Very High Very High Very High
Alcohol Addiction 2 97.20 Very High Very High Very High
Sprains And Strains 3 91.64 High High
INFLAMMATION 32 85.12 High High
Respiratory Disease 4 81.12 Quite High
Sepsis 8 78.08 Quite High
Lung Injury 52 76.56 Quite High
Injury 56 5.00 Very Low Very Low Very Low
Pulmonary Edema 8 5.00 Very Low Very Low Very Low
Leukemia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significant decrease in the NEP enzymatic activity in the lung of mice with ALI was associated with a lower level of its gene expression in the lung, suggesting that the downregulation of NEP activity was due to its decreased expression at the transcriptional level responsible for ALI/ARDS.
Transcription (expression) of NEP in lung associated with adult respiratory distress syndrome
1) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.16 Pain Relevance 0.04
We also studied the distribution and measured the amounts of NEP protein, using immuno-histochemical and immunoblot analyses, and measured the levels of NEP mRNA, using real-time reverse transcription-polymerase chain reaction, in the lungs of mice with ALI.


Transcription (levels) of NEP in lungs associated with adult respiratory distress syndrome
2) Confidence 0.53 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 1.30 Pain Relevance 0.03
The NEP mRNA levels were significantly lower in the lungs of 5 LPS-treated mice than in the lungs of 4 mice treated with saline alone (Figure 7).


Transcription (levels) of NEP in lungs
3) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.58 Pain Relevance 0
To study the transcriptional regulation of the NEP gene, we also measured the NEP mRNA levels in lung tissue of mice with ALI, using semi-quantitative RT-PCR.
Transcription (levels) of NEP in lung associated with adult respiratory distress syndrome
4) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.63 Pain Relevance 0
In the first experiment, basal mRNA levels of mu- and delta-opioid receptors, and of opioid-degrading enzymes enkephalinase (neutral endopeptidase 24.11; NEP) and angiotensin-converting enzyme (ACE) in the brain regions of C57BL/6 and DBA/2 mice did not reveal genetically determined differences in these parameters between the two strains.
Transcription (levels) of enkephalinase in brain associated with delta opioid receptors, sprains and strains and opioid
5) Confidence 0.33 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.35 Pain Relevance 0.37

General Comments

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