INT7773

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Context Info
Confidence 0.55
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 8.54
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SERPINF1) extracellular space (SERPINF1) aging (SERPINF1)
extracellular region (SERPINF1)
Anatomy Link Frequency
endothelium 6
fibroblast 3
macrophage 2
endothelial cells 2
spinal 1
SERPINF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 100.00 Very High Very High Very High
Central nervous system 18 100.00 Very High Very High Very High
agonist 10 99.06 Very High Very High Very High
anesthesia 10 97.08 Very High Very High Very High
Inflammation 4 97.04 Very High Very High Very High
Nicotine 9 96.24 Very High Very High Very High
adenocard 7 96.16 Very High Very High Very High
Clonidine 12 95.88 Very High Very High Very High
bradykinin 1 93.22 High High
Migraine 7 89.32 High High
Disease Link Frequency Relevance Heat
Cancer 12 99.88 Very High Very High Very High
Choroideremia 830 99.74 Very High Very High Very High
Necrosis 10 99.64 Very High Very High Very High
Increased Venous Pressure Under Development 18 97.82 Very High Very High Very High
Hyperlipidemia 10 97.44 Very High Very High Very High
INFLAMMATION 4 97.04 Very High Very High Very High
Adhesions 25 94.04 High High
Targeted Disruption 20 90.88 High High
Pressure Volume 2 Under Development 3 90.64 High High
Headache 9 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The late vasodepressor response may involve three different mechanisms: (1) direct vasorelaxation by activation of 5-HT(7) receptors located on vascular smooth muscle; (2) inhibition of the vasopressor sympathetic outflow by sympatho-inhibitory 5-HT(1A/1B/1D) receptors; and (3) release of endothelium-derived relaxing factor (nitric oxide) by 5-HT(2B) and/or 5-HT(1B/1D) receptors.
Localization (release) of endothelium-derived relaxing factor in endothelium
1) Confidence 0.55 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17703282 Disease Relevance 0.53 Pain Relevance 0.10
We conclude from these studies that in arteries obtained from hypercholesterolemic rabbits: the contractions caused by serotonergic mechanisms tend to be augmented, while those to alpha-adrenergic activation are decreased, the endothelium-independent relaxations are modified only in the more severely affected arteries, and the endothelium-dependent relaxations are progressively inhibited as the degree of fatty streak formation augments, probably because a step subsequent to the release of endothelium-derived relaxant factor is altered.
Localization (release) of endothelium-derived relaxant factor in endothelium
2) Confidence 0.55 Published 1986 Journal Circ. Res. Section Abstract Doc Link 3486053 Disease Relevance 0.16 Pain Relevance 0.03
The acetylcholine-induced release of endothelium-derived relaxant factor from the abdominal aorta was not significantly affected by the hypercholesterolemia.
Localization (release) of endothelium-derived relaxant factor in abdominal aorta associated with hyperlipidemia
3) Confidence 0.55 Published 1986 Journal Circ. Res. Section Abstract Doc Link 3486053 Disease Relevance 0.24 Pain Relevance 0.14
Secreted central nervous system proteins included PEDF [55], CNDP1 [54], and autotaxin [56].
Localization (Secreted) of PEDF in central nervous system associated with central nervous system
4) Confidence 0.45 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.50 Pain Relevance 0.21
Finally, CHM fibroblasts secreted significantly lower levels of cytokine/growth factors such as macrophage chemoattractant protein-1 (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (lL)-8.


Localization (secreted) of PEDF in fibroblast associated with necrosis, cancer, choroideremia and cytokine
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793004 Disease Relevance 0.99 Pain Relevance 0.09
In contrast, fibroblasts from CHM patients, when compared to normal controls, secreted significantly lower levels of MCP-1, PEDF, TNF-alpha, FGF and IL-8.
Localization (secreted) of PEDF in fibroblasts associated with choroideremia
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.73 Pain Relevance 0
CHM fibroblasts secreted significantly lower levels of macrophage chemoattractant protein (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (IL)-8 into the media.
Localization (secreted) of pigment epithelial derived factor in macrophage associated with necrosis, cancer and choroideremia
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.99 Pain Relevance 0
CHM fibroblasts secreted significantly lower levels of macrophage chemoattractant protein (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (IL)-8 into the media.
Localization (secreted) of PEDF in macrophage associated with necrosis, cancer and choroideremia
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.99 Pain Relevance 0
Finally, CHM fibroblasts secreted significantly lower levels of cytokine/growth factors such as macrophage chemoattractant protein-1 (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (lL)-8.


Localization (secreted) of pigment epithelial derived factor in fibroblast associated with necrosis, cancer, choroideremia and cytokine
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793004 Disease Relevance 0.99 Pain Relevance 0.09
Acetylcholine stimulates muscarinic receptors of endothelial cells resulting in the release of endothelium-derived relaxing factor (EDRF), and possibly nitric oxide.
Localization (release) of endothelium-derived relaxing factor in endothelial cells
10) Confidence 0.19 Published 1999 Journal Pharmacology Section Abstract Doc Link 9873232 Disease Relevance 0.05 Pain Relevance 0.41
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Localization (several) of PEDF
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Localization (morphogens) of PEDF
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
Because activation of alpha2-adrenoceptors on endothelial cells induces release of endothelium-derived relaxing factor (EDRF), we determined whether nitric oxide (NO) release is involved in the antihypertensive action of clonidine and rilmenidine.
Localization (release) of endothelium-derived relaxing factor in endothelium associated with clonidine
13) Confidence 0.04 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10813383 Disease Relevance 0.21 Pain Relevance 0.44
In endothelium-denuded vessels relaxation was absent. 5-HT-induced relaxation of precontracted pulmonary arteries was probably mediated by release of an endothelium-derived relaxing factor (EDRF).
Localization (release) of endothelium-derived relaxing factor in endothelium
14) Confidence 0.04 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8391650 Disease Relevance 0 Pain Relevance 0.10
Recent studies have shown that the ATP-induced cerebral vasodilation is endothelium-dependent via activation of P2Y-purinoceptors on the endothelial cell surface and subsequent release of endothelium-derived relaxing factor (EDRF); and that the endothelial cells are the main local source of the ATP involved, although adenosine 5'-diphosphate and ATP released from aggregating platelets may also contribute to this vasodilatation.
Localization (release) of endothelium-derived relaxing factor in endothelial cell associated with adenocard and increased venous pressure under development
15) Confidence 0.01 Published 1989 Journal Biomed. Pharmacother. Section Abstract Doc Link 2701287 Disease Relevance 1.56 Pain Relevance 1.00
Localization (e. The ) of endothelium-derived hyperpolarizing factor
16) Confidence 0.01 Published 2007 Journal Vascul. Pharmacol. Section Title Doc Link 17049314 Disease Relevance 0.08 Pain Relevance 0.14
The isolated perfused rat mesenteric bed releases endothelium-derived hyperpolarizing factor (EDHF) in response to acetylcholine (ACh) or histamine.
Localization (releases) of endothelium-derived hyperpolarizing factor in endothelium
17) Confidence 0.01 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9234831 Disease Relevance 0 Pain Relevance 0.09
To examine the modification of the action of ET-1 on the blood vessels by the baroceptor reflex or by the endothelium-derived relaxing factor (EDRF) released by ET-1 in phase 1, we performed experiments in dogs under total spinal anesthesia (TSA group), methylene blue-treated dogs (MB group) as well as in the untreated dogs (control group).
Localization (released) of endothelium-derived relaxing factor in spinal associated with anesthesia
18) Confidence 0.01 Published 1992 Journal Jpn. Circ. J. Section Abstract Doc Link 1356165 Disease Relevance 0.34 Pain Relevance 0.10
These results suggest that the impairment of relaxation by alpha(2)-agonists in SHRSP is not caused by the increase in the release of endothelium-derived contracting factor (EDCF) but by the reduction in the release of nitric oxide (NO).
Localization (release) of endothelium-derived contracting factor in endothelium associated with agonist
19) Confidence 0.00 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8859945 Disease Relevance 0.19 Pain Relevance 0.32

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