INT77737

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc, Prl)
Pnoc (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 8 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
Intracerebroventricular 1 98.96 Very High Very High Very High
narcan 3 98.56 Very High Very High Very High
opiate 3 90.40 High High
antagonist 3 89.36 High High
agonist 2 77.32 Quite High
opioid receptor 1 57.12 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Phe(1)Psi(CH(2)-NH)Gly(2)]NC(1-13)NH(2) does not antagonize orphaninFQ/nociceptin-induced prolactin release.
nociceptin Positive_regulation (induced) of Localization (release) of prolactin associated with orphanin and narcan
1) Confidence 0.55 Published 2002 Journal Brain Res. Bull. Section Title Doc Link 11927375 Disease Relevance 0 Pain Relevance 0.44
Orphanin FQ/nociceptin (OFQ/N), the most recently identified endogenous opioid peptide, stimulates prolactin secretion in both male and female rats.
Orphanin FQ Positive_regulation (stimulates) of Localization (secretion) of prolactin associated with orphanin and endogenous opioid
2) Confidence 0.54 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887913 Disease Relevance 0 Pain Relevance 0.39
Orphanin FQ stimulates prolactin and growth hormone release in male and female rats.
Orphanin FQ Positive_regulation (stimulates) of Localization (release) of prolactin associated with orphanin
3) Confidence 0.29 Published 1998 Journal Brain Res. Section Title Doc Link 9757048 Disease Relevance 0 Pain Relevance 0.23

General Comments

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