INT77752

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.22
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1c) plasma membrane (Cacna1c) nucleus (Cacna1c)
transmembrane transport (Cacna1c) cytoplasm (Cacna1c)
Cacna1c (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 16 100.00 Very High Very High Very High
Calcium channel 2 99.96 Very High Very High Very High
agonist 1 97.52 Very High Very High Very High
antinociception 1 96.64 Very High Very High Very High
Neurotransmitter 1 89.28 High High
Potency 1 83.68 Quite High
Dopamine 2 80.64 Quite High
analgesia 1 75.00 Quite High
local anesthetic 4 72.60 Quite High
Pain 2 72.28 Quite High
Disease Link Frequency Relevance Heat
Hypertension 1 77.84 Quite High
Pain 1 72.28 Quite High
Stroke 1 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to investigate the pharmacokinetic interaction of morphine with three classes of L-type calcium channel blockers (CCB) and its relationship to morphine-induced mechanical antinociception in mice.
L-type Binding (interaction) of associated with antinociception, calcium channel and morphine
1) Confidence 0.22 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15037808 Disease Relevance 0 Pain Relevance 0.85
Molecular basis of drug interaction with L-type Ca2+ channels.
L-type Ca2 Binding (interaction) of
2) Confidence 0.19 Published 1998 Journal J. Bioenerg. Biomembr. Section Title Doc Link 9758329 Disease Relevance 0.22 Pain Relevance 0.12
These observations suggested that low concentrations of OXZ interact with L-type Ca(2+) channels.
L-type Binding (interact) of
3) Confidence 0.00 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12167487 Disease Relevance 0 Pain Relevance 0.34

General Comments

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