INT7776

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 63
Total Number 71
Disease Relevance 21.35
Pain Relevance 14.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Anatomy Link Frequency
CSCs 7
brain 5
liver 3
spleen 3
colon 2
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 74 99.92 Very High Very High Very High
vincristine 62 99.84 Very High Very High Very High
Oxycodone 18 99.82 Very High Very High Very High
Analgesic 13 99.52 Very High Very High Very High
cocaine 160 99.40 Very High Very High Very High
methadone 390 98.62 Very High Very High Very High
isoflurane 4 98.40 Very High Very High Very High
Cancer pain 6 96.64 Very High Very High Very High
Opioid 16 96.48 Very High Very High Very High
Central nervous system 32 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 11 99.96 Very High Very High Very High
Inflammatory Bowel Disease 32 99.68 Very High Very High Very High
Cancer 1684 99.32 Very High Very High Very High
Leukemia 38 99.16 Very High Very High Very High
Breast Cancer 661 98.40 Very High Very High Very High
Colon Cancer 155 98.00 Very High Very High Very High
Sprains And Strains 210 97.92 Very High Very High Very High
Cancer Pain 6 96.64 Very High Very High Very High
Recurrence 59 93.52 High High
Toxicity 135 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using Western blot analysis and cytotoxicity assays respectively, we have investigated the effects of short-term (72 h) morphine treatment on P-glycoprotein expression in a panel of human cancer cell lines, and its effects on cellular resistance to the known P-glycoprotein substrates, vinblastine and colchicine.
Gene_expression (expression) of P-glycoprotein associated with cancer and morphine
1) Confidence 0.75 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.41 Pain Relevance 0.83
Furthermore, there was a significant negative correlation between morphine's analgesic effects and individual P-gp expression in the cortex as estimated by western blot analysis.
Gene_expression (expression) of P-gp in cortex associated with analgesic and morphine
2) Confidence 0.75 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18071274 Disease Relevance 0 Pain Relevance 1.38
We previously found that morphine and fentanyl showed higher analgesic potencies in P-gp-deficient mice compared with those in wild-type mice, suggesting that their analgesic effects are considerably dependent on P-gp expression.
Gene_expression (expression) of P-gp associated with analgesic and morphine
3) Confidence 0.75 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18071274 Disease Relevance 0 Pain Relevance 1.09
In addition, a polymorphism of MDR1 gene, associated with a variability of the expression of P-glycoprotein in the intestine, has been reported in humans [61-64].
Gene_expression (expression) of P-glycoprotein in intestine
4) Confidence 0.75 Published 2003 Journal Filaria J Section Body Doc Link PMC2147657 Disease Relevance 0.72 Pain Relevance 0.03
One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].
Gene_expression (expression) of P-glycoprotein in CSCs
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.21 Pain Relevance 0
Ixabepilone is 108 to 529 times more potent than taxanes or doxorubicin in the P-glycoprotein expressing hepatocellular carcinoma cell line SNU-449 (Mok et al 2006).
Gene_expression (expressing) of P-glycoprotein in SNU-449 associated with hepatocellular cancer
6) Confidence 0.75 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.26 Pain Relevance 0
However, it was clearly shown that among various P-glycoprotein-overexpressing multidrug resistant human tumor sublines tested in vitro, the level of cross-resistance expressed with VFL was generally far lower than that of vinorelbine or vincristine.
Gene_expression (overexpressing) of P-glycoprotein associated with vincristine and cancer
7) Confidence 0.75 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643105 Disease Relevance 0.79 Pain Relevance 0.05
This phenomenon is based on the fact that methadone is a substrate of the ATP-dependent efflux transporter protein, the P-glycoprotein (P-gp) which is expressed in the brush-border membranes of the maternal derived syncytiotrophoblast and works against the concentration gradient [7,9,10].
Gene_expression (expressed) of P-glycoprotein in syncytiotrophoblast associated with methadone
8) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2703629 Disease Relevance 0.79 Pain Relevance 1.05
Epothilones are poor substrates for P-glycoprotein and are cytotoxic in cell lines that express high levels of P-glycoprotein (Lehne 2000).
Gene_expression (express) of P-glycoprotein
9) Confidence 0.75 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.22 Pain Relevance 0.03
This drug is also highly active in cell lines expressing P-glycoprotein efflux pumps (Hoffmann et al 2008).
Gene_expression (expressing) of P-glycoprotein
10) Confidence 0.75 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.27 Pain Relevance 0
Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.
Gene_expression (overexpression) of ABCB1 associated with oxycodone
11) Confidence 0.75 Published 2007 Journal J Pharm Sci Section Title Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.64
Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.
Gene_expression (overexpression) of P-glycoprotein associated with oxycodone
12) Confidence 0.75 Published 2007 Journal J Pharm Sci Section Title Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.64
Minimum alveolar concentration (MAC) for isoflurane is not affected by systemic ondansetron; however ondansetron is a substrate of P-glycoprotein, a transport pump expressed in the blood-brain barrier.
Gene_expression (expressed) of P-glycoprotein in brain associated with isoflurane
13) Confidence 0.75 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16931690 Disease Relevance 0.21 Pain Relevance 0.22
Evidence for expression of P-glycoprotein.
Gene_expression (expression) of P-glycoprotein
14) Confidence 0.75 Published 1992 Journal Neoplasma Section Title Doc Link 1356238 Disease Relevance 0.20 Pain Relevance 0.43
This cell line was obtained by long-term adaptation of the L1210 mouse leukaemic cell line on vincristine and showed an overexpression of P-glycoprotein and accompanying multidrug resistance (MDR) which was defined as a cell resistance to several cytostatics such as vincristine, vinblastine and actinomycin D.
Gene_expression (overexpression) of P-glycoprotein in L1210 associated with vincristine
15) Confidence 0.75 Published 1994 Journal Drugs Exp Clin Res Section Abstract Doc Link 7924890 Disease Relevance 0 Pain Relevance 0.23
P-glycoprotein (P-gp) and organic anion transporting polypeptides (Oatp) are expressed at the blood-brain barrier (BBB).
Gene_expression (expressed) of P-glycoprotein in brain
16) Confidence 0.75 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11257421 Disease Relevance 0 Pain Relevance 0.29
As recent genomic data has determined that P-glycoprotein is over expressed in clinical samples of human Her2/neu+ breast cancer, these agents may be of particular value in this subset of patients (O'Brien et al 2008).
Gene_expression (expressed) of P-glycoprotein associated with breast cancer
17) Confidence 0.75 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.17 Pain Relevance 0
Recently, morphine has been shown to induce P-glycoprotein expression in the rat brain.
Gene_expression (expression) of P-glycoprotein in brain associated with morphine
18) Confidence 0.75 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.34 Pain Relevance 0.74
One important factor in the development of MDR is overexpression of P-glycoprotein, encoded by the MDR1 gene.
Gene_expression (overexpression) of P-glycoprotein
19) Confidence 0.75 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.33 Pain Relevance 0.58
Short-term exposure to morphine did not result in any significant differences in P-glycoprotein expression or activity in any cancer cell lines.
Gene_expression (expression) of P-glycoprotein associated with cancer and morphine
20) Confidence 0.75 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.40 Pain Relevance 0.99

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