INT77782

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
neurons 2
Schwann cell 2
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 10 99.68 Very High Very High Very High
Dorsal horn 104 98.76 Very High Very High Very High
intrathecal 2 96.40 Very High Very High Very High
Hyperalgesia 5 90.08 High High
Sciatic nerve 7 89.64 High High
Peripheral nerve injury 16 87.12 High High
spinal dorsal horn 3 81.40 Quite High
Glutamate 7 80.20 Quite High
cytokine 18 54.88 Quite High
Dorsal horn neuron 13 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nociception 4 99.74 Very High Very High Very High
Neuropathic Pain 29 99.68 Very High Very High Very High
Hyperalgesia 5 90.08 High High
Nervous System Injury 96 86.24 High High
Necrosis 7 55.48 Quite High
Cancer 7 55.12 Quite High
Injury 7 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that TX14(A) decreased nociceptive behavior by attenuating both TNFR1 upregulation and Schwann cell activation in response to TNF injection.
Negative_regulation (attenuating) of Positive_regulation (upregulation) of TNFR1 in Schwann cell associated with nociception
1) Confidence 0.41 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.80 Pain Relevance 0.31
Intrathecal delivery of PDTC (8.2 ng in 10 microl volume), a nuclear factor-kappa B (NF-kappaB) inhibitor, 30 min before each rrTNF administration blocked mechanical allodynia completely and inhibited the upregulation of TNF-alpha-IR and TNFR1-IR substantially.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of TNFR1 associated with allodynia and intrathecal
2) Confidence 0.38 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.23 Pain Relevance 0.50
Interestingly, while TNFR1 activation also decreases the exocytosis of GABAARs in hippocampal neurons [26], we observed no significant effects of TNF?
Negative_regulation (decreases) of Positive_regulation (activation) of TNFR1 in neurons
3) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.17 Pain Relevance 0.36

General Comments

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