INT77784

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.61
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
neuronal 1
neurons 1
nerve 1
DRG 1
Tnfrsf1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 28 99.58 Very High Very High Very High
Glutamate 6 99.32 Very High Very High Very High
Hyperalgesia 4 98.78 Very High Very High Very High
Spinal nerve ligature 5 98.60 Very High Very High Very High
cytokine 16 97.88 Very High Very High Very High
dorsal root ganglion 7 95.36 Very High Very High Very High
rheumatoid arthritis 16 92.32 High High
Dermatone 1 91.72 High High
allodynia 1 90.32 High High
Snapping jaw 1 87.56 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 13 99.98 Very High Very High Very High
Toxicity 8 99.50 Very High Very High Very High
Nervous System Injury 4 99.36 Very High Very High Very High
Hyperalgesia 4 98.78 Very High Very High Very High
Ganglion Cysts 9 95.36 Very High Very High Very High
Cancer 10 95.24 Very High Very High Very High
Necrosis 9 95.00 High High
Rheumatoid Arthritis 17 92.32 High High
INFLAMMATION 36 90.64 High High
Neuropathic Pain 2 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFR2 was exclusively expressed and regulated in non-neuronal cells.
Regulation (regulated) of TNFR2 in neuronal
1) Confidence 0.57 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 1.00 Pain Relevance 0.45
Biomechanical strain regulates TNFR2 but not TNFR1 in TMJ cells.
Regulation (regulates) of TNFR2 associated with inflammation and sprains and strains
2) Confidence 0.41 Published 2007 Journal J Biomech Section Title Doc Link 17049356 Disease Relevance 1.16 Pain Relevance 0.18
Here we report the design and characterization of this high affinity TNFR2-Fc variant, and focus on evaluating its therapeutic effect of neutralizing activity of TNF?
Regulation (affinity) of TNFR2
3) Confidence 0.40 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816690 Disease Relevance 0.20 Pain Relevance 0.10
Hence there was an up-regulation of pathways such as nfkb, rela, tnfr2 and tob1 while there was a down-regulation of FAS.
Regulation (regulation) of tnfr2
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.06 Pain Relevance 0.08
In L4 (uninjured) DRG, TNFR1 and TNFR2 immunoreactivity peaked at 24 h returning to basal levels by 120 h.
Regulation (immunoreactivity) of TNFR2 in DRG
5) Confidence 0.26 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12875915 Disease Relevance 0.57 Pain Relevance 0.83
In cortical neurons exposed to glutamate toxicity, the signaling pathways involve TNFR1 and TNFR2 [17].
Regulation (involve) of TNFR2 in neurons associated with toxicity and glutamate
6) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.78 Pain Relevance 0.16
Efforts to elucidate TX14(A) antagonism of hyperalgesia concentrated on determining the effect of TX14(A) on the up-regulation of the 55 kDa TNF receptor (TNFR1) at the nerve injury site.
Regulation (regulation) of TNF receptor in nerve associated with hyperalgesia and nervous system injury
7) Confidence 0.05 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.84 Pain Relevance 0.36

General Comments

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