INT77785

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.10
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
macrophages 2
neuronal 2
nerve 2
lung 2
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 28 99.90 Very High Very High Very High
dorsal root ganglion 46 96.08 Very High Very High Very High
cytokine 22 94.92 High High
qutenza 1 86.44 High High
Inflammation 86 82.56 Quite High
Thermal hyperalgesia 6 80.76 Quite High
ectopic activity 1 76.08 Quite High
Inflammatory mediators 5 75.76 Quite High
Antihyperalgesic 3 66.48 Quite High
Etanercept 27 62.80 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 37 99.90 Very High Very High Very High
Apoptosis 44 98.12 Very High Very High Very High
Nociception 12 96.16 Very High Very High Very High
Ganglion Cysts 46 96.08 Very High Very High Very High
Cancer 15 94.56 High High
Necrosis 17 94.32 High High
Death 10 83.48 Quite High
INFLAMMATION 93 82.56 Quite High
Adult Respiratory Distress Syndrome 22 80.04 Quite High
Nervous System Injury 11 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prosaptide prevents hyperalgesia and reduces peripheral TNFR1 expression following TNF-alpha nerve injection.
Negative_regulation (reduces) of Gene_expression (expression) of TNFR1 in nerve associated with hyperalgesia
1) Confidence 0.56 Published 1998 Journal Neuroreport Section Title Doc Link 9760128 Disease Relevance 0.87 Pain Relevance 0.39
during the structural regression of the CL by analysis of TNFR expression, and to determine the role of TNF?
Negative_regulation (analysis) of Gene_expression (expression) of TNFR
2) Confidence 0.37 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.23 Pain Relevance 0
Recently, increased neuronal TNFR1 expression was reported in association with intraperitoneal lipopolysaccharide [13], suggesting a direct TNF effect on nociceptive pathways via TNFR1.
Negative_regulation (reported) of Gene_expression (expression) of TNFR1 in neuronal associated with nociception
3) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.00 Pain Relevance 0.69
Such a protection might have resulted from a decrease in TNFR1 expression on lung cells, needed for stimulation of the TNF-induced signaling pathway of apoptosis, and from inhibition of a key caspase downstream in the pathway, which was previously shown by this laboratory to include caspase-3 [31].


Negative_regulation (decrease) of Gene_expression (expression) of TNFR1 in lung associated with apoptosis
4) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0.65 Pain Relevance 0.09
In addition to its effect on the influx of both leukocytes and neutrophils into the lung airspaces, TAU was also found here to attenuate the expression of TNFR1 on macrophages present in BALF as a result of an exposure to LPS, again to a greater extent when given before than after LPS.
Negative_regulation (attenuate) of Gene_expression (expression) of TNFR1 in macrophages
5) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0.35 Pain Relevance 0.18

General Comments

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