INT77786

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.03
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
sensory neurons 1
nerve 1
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 16 99.84 Very High Very High Very High
intrathecal 2 98.42 Very High Very High Very High
cytokine 5 95.68 Very High Very High Very High
Hyperalgesia 12 95.44 Very High Very High Very High
Pain 6 95.04 Very High Very High Very High
headache 2 89.96 High High
Inflammation 14 89.80 High High
Etanercept 41 74.00 Quite High
Kinase C 1 60.00 Quite High
IPN 1 58.00 Quite High
Disease Link Frequency Relevance Heat
Headache 18 99.84 Very High Very High Very High
Hyperalgesia 16 99.40 Very High Very High Very High
Necrosis 9 99.36 Very High Very High Very High
Cancer 6 99.18 Very High Very High Very High
Nociception 2 98.76 Very High Very High Very High
Pressure And Volume Under Development 11 97.76 Very High Very High Very High
Nervous System Injury 3 97.12 Very High Very High Very High
Pain 5 95.04 Very High Very High Very High
INFLAMMATION 12 89.80 High High
Apoptosis 7 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiments, TNFR1 was decreased at the TNF nerve injection site in TX14(A)-treated rats when compared to vehicle-treated or control peptide-treated rats.
Negative_regulation (decreased) of TNFR1 in nerve
1) Confidence 0.56 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.91 Pain Relevance 0.35
Intrathecal administration of antisense to tumour necrosis factor receptor type-1 (TNFR1) reduced the level of TNFR1 transported toward the peripheral terminals of sensory neurons, and attenuated both carrageenan- and rrTNFalpha-induced priming.
Negative_regulation (reduced) of TNFR1 in sensory neurons associated with necrosis, cancer and intrathecal
2) Confidence 0.42 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12752784 Disease Relevance 1.43 Pain Relevance 0.92
However, The CRD2 and CDR3 of TNFR2 showed a considerable degree of sequence identity with TNFR1 (?
Negative_regulation (degree) of TNFR1
3) Confidence 0.31 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816690 Disease Relevance 0.11 Pain Relevance 0.18
The TUNEL evaluation was positive in the panniculus carnosus densely at P7 (Fig 5, center) and sparsely at P30 but negative at P60 (Fig 5, right), P90, and P180 as well as in controls at day 0 (Fig 5, left) and controls at day 180.
Negative_regulation (positive) of P60
4) Confidence 0.05 Published 2010 Journal Eplasty Section Body Doc Link PMC2878756 Disease Relevance 0.17 Pain Relevance 0
Decreased sTNF-RI in migraine patients?
Negative_regulation (Decreased) of sTNF-RI associated with migraine
5) Confidence 0.01 Published 2003 Journal Cephalalgia Section Title Doc Link 12534582 Disease Relevance 1.13 Pain Relevance 1.03
If TNF-alpha plays a role in migraine physiopathology, migraine patients may lack sufficient antagonistic sTNF-RI to neutralize hyperalgesic TNF-alpha during a migraine attack.
Spec (may) Negative_regulation (lack) of sTNF-RI associated with hyperalgesia and migraine
6) Confidence 0.00 Published 2003 Journal Cephalalgia Section Abstract Doc Link 12534582 Disease Relevance 1.29 Pain Relevance 1.09

General Comments

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