INT77788

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 11.24
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
neurons 2
dorsal root ganglia 2
sensory neurons 1
nerve 1
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 3 100.00 Very High Very High Very High
dorsal root ganglion 53 99.84 Very High Very High Very High
Inflammation 76 99.72 Very High Very High Very High
Glutamate 5 99.32 Very High Very High Very High
Spinal nerve ligature 5 99.00 Very High Very High Very High
Hyperalgesia 28 98.78 Very High Very High Very High
Calcitonin gene-related peptide 1 96.80 Very High Very High Very High
substance P 1 95.48 Very High Very High Very High
Dermatone 1 92.12 High High
allodynia 6 90.72 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 22 99.98 Very High Very High Very High
Ganglion Cysts 59 99.84 Very High Very High Very High
INFLAMMATION 86 99.72 Very High Very High Very High
Nervous System Injury 13 99.72 Very High Very High Very High
Toxicity 8 99.50 Very High Very High Very High
Necrosis 37 99.08 Very High Very High Very High
Cancer 32 98.90 Very High Very High Very High
Hyperalgesia 37 98.78 Very High Very High Very High
Nociception 14 98.04 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 8 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the expression pattern and regulation of TNFR1a, TRADD, and the executioner protease, Caspase 3, indicate that the extrinsic pathway to apoptosis [43] is active in RGCs undergoing IONT or IONC.
Regulation (regulation) of TNFR1a associated with apoptosis
1) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 0.97 Pain Relevance 0.06
Biomechanical strain regulates TNFR2 but not TNFR1 in TMJ cells.
Regulation (regulates) of TNFR1 associated with inflammation and sprains and strains
2) Confidence 0.55 Published 2007 Journal J Biomech Section Title Doc Link 17049356 Disease Relevance 1.17 Pain Relevance 0.18
There was no change in TNFR1 mRNA levels when compared to Day 16 of pregnancy; however, there was a significant increase in TNFR1 mRNA levels from Day 22 of pregnancy to Day 3 post-partum.
Neg (no) Regulation (change) of TNFR1 mRNA
3) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.25 Pain Relevance 0
The hypothesis of this study was that CL fate might be regulated at the level of the TNFR; should only one receptor type be expressed during CL regression.
Spec (might) Regulation (regulated) of TNFR
4) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.25 Pain Relevance 0
TRAPS is the first condition for which naturally occurring mutations in a TNF receptor were found; the mutations affect the soluble TNFRSF1A gene in the 12p13 region.
Regulation (affect) of TNFRSF1A gene associated with tumor necrosis factor receptor-associated periodic syndrome
5) Confidence 0.48 Published 2004 Journal Joint Bone Spine Section Abstract Doc Link 15288852 Disease Relevance 1.87 Pain Relevance 0.19
These findings are the first to show that biomechanical signals regulate the expression of TNFR2 but not TNFR1 under inflammatory conditions.
Neg (not) Regulation (regulate) of TNFR1 associated with inflammation
6) Confidence 0.40 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 0.99 Pain Relevance 0.13
Previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor 1 (TNFR1) in dorsal root ganglia (DRG) and in spinal dorsal horn are upregulated after nerve injury and that many TNF-alpha-containing neurons overexpress TNFR1.
Regulation (upregulated) of TNFR1 in dorsal root ganglia associated with necrosis, nervous system injury, cancer and spinal dorsal horn
7) Confidence 0.40 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.45 Pain Relevance 0.24
In L4 (uninjured) DRG, TNFR1 and TNFR2 immunoreactivity peaked at 24 h returning to basal levels by 120 h.
Regulation (immunoreactivity) of TNFR1 in DRG
8) Confidence 0.27 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12875915 Disease Relevance 0.57 Pain Relevance 0.83
Double ISH revealed varying levels of TNFR1 mRNA in virtually all DRG neurons including putative nociceptive neurons coding for calcitonin gene-related peptide, substance P, or vanilloid receptor 1.
Regulation (varying) of TNFR1 mRNA in neurons associated with nociception, dorsal root ganglion, substance p and calcitonin gene-related peptide
9) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 0.97 Pain Relevance 0.47
Efforts to elucidate TX14(A) antagonism of hyperalgesia concentrated on determining the effect of TX14(A) on the up-regulation of the 55 kDa TNF receptor (TNFR1) at the nerve injury site.
Regulation (regulation) of TNFR1 in nerve associated with hyperalgesia and nervous system injury
10) Confidence 0.26 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.84 Pain Relevance 0.36
In cortical neurons exposed to glutamate toxicity, the signaling pathways involve TNFR1 and TNFR2 [17].
Regulation (involve) of TNFR1 in neurons associated with toxicity and glutamate
11) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.78 Pain Relevance 0.16
There was a slight but insignificant change in TNFR1 mRNA levels between Day 16 and Day 22 of pregnancy (Figure 5a), but levels increased significantly (P < 0.05) from Day 22 of pregnancy to Day 3 post-partum.
Regulation (change) of TNFR1 mRNA
12) Confidence 0.24 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0 Pain Relevance 0
The present study has shown that chronic inflammation is associated with up-regulation of TNFR1 on DRG neurons, thereby providing an opportunity for direct interaction between TNF and sensory neurons.
Regulation (regulation) of TNFR1 in sensory neurons associated with dorsal root ganglion and inflammation
13) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.61 Pain Relevance 0.82
In contrast to these changes in TNF-R1 there were no significant changes in the levels or distributions of FasL or Nur77 in NMDA-stimulated animals at either 2 or 24 h when compared to the sham-controls.
Regulation (changes) of TNF-R1
14) Confidence 0.19 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12531535 Disease Relevance 0.22 Pain Relevance 0.07
Results: Significant reductions in panniculus carnosus thickness were observed between controls and irradiated tissues at postirradiation day 30 (P30), P60, P90, and P180; however, no reduction was observed in nonirradiated controls from days 0 to 180.
Regulation (controls) of P60
15) Confidence 0.06 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2878756 Disease Relevance 0.30 Pain Relevance 0

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