INT7779

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1983
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 47
Total Number 48
Disease Relevance 9.45
Pain Relevance 28.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
FCX 3
brain 2
locus coeruleus 2
medulla 2
neurons 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 117 100.00 Very High Very High Very High
agonist 59 100.00 Very High Very High Very High
antagonist 50 100.00 Very High Very High Very High
Locus ceruleus 20 100.00 Very High Very High Very High
opiate 9 100.00 Very High Very High Very High
cocaine 27 99.98 Very High Very High Very High
isoflurane 6 99.98 Very High Very High Very High
narcan 14 99.88 Very High Very High Very High
adenocard 4 99.88 Very High Very High Very High
Analgesic 3 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 1 99.96 Very High Very High Very High
Heart Rate Under Development 15 99.84 Very High Very High Very High
Urological Neuroanatomy 26 99.80 Very High Very High Very High
Shock 14 99.78 Very High Very High Very High
Mydriatic 10 99.60 Very High Very High Very High
Nervous System Injury 18 99.36 Very High Very High Very High
Pressure Volume 2 Under Development 2 97.80 Very High Very High Very High
Neuropathic Pain 15 96.92 Very High Very High Very High
Pain 5 96.64 Very High Very High Very High
Cv Unclassified Under Development 8 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tramadol (20 mg/kg, i.p.) administered acutely (single dose), at 24 h after dosing, induced a significant decrease in the alpha2-adrenergic receptors in all brain regions studied.
Negative_regulation (decrease) of alpha2-adrenergic in brain associated with tramadol
1) Confidence 0.58 Published 2004 Journal Brain Res. Section Abstract Doc Link 15246863 Disease Relevance 0.08 Pain Relevance 0.76
The alpha 2-adrenoceptor mediated reduction produced by clonidine (100 microM) was antagonised by the selective alpha 2-antagonist idazoxan (RX781094) (200 microM).
Negative_regulation (reduction) of alpha 2-adrenoceptor associated with antagonist and clonidine
2) Confidence 0.49 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2891545 Disease Relevance 0 Pain Relevance 0.81
Chronic administration of cocaine significantly (compared to sham controls) attenuated the alpha 2-adrenoceptor-mediated inhibition of noradrenergic locus coeruleus (LC) neurons as well as alpha 2-adrenoceptor elicited mydriasis.
Negative_regulation (inhibition) of alpha 2-adrenoceptor in locus coeruleus associated with mydriatic, locus ceruleus and cocaine
3) Confidence 0.43 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2547625 Disease Relevance 0.25 Pain Relevance 0.64
Chronic administration of cocaine significantly (compared to sham controls) attenuated the alpha 2-adrenoceptor-mediated inhibition of noradrenergic locus coeruleus (LC) neurons as well as alpha 2-adrenoceptor elicited mydriasis.
Negative_regulation (inhibition) of alpha 2-adrenoceptor in locus coeruleus associated with mydriatic, locus ceruleus and cocaine
4) Confidence 0.43 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2547625 Disease Relevance 0.24 Pain Relevance 0.59
In the rat vena cava preincubated with [3H]-noradrenaline, the B-HT 920-induced alpha 2-adrenoceptor-mediated inhibition of electrically evoked tritium overflow was also reduced at lower temperature. 5.
Negative_regulation (inhibition) of alpha 2-adrenoceptor-mediated in vena cava associated with noradrenaline
5) Confidence 0.43 Published 1990 Journal J Auton Pharmacol Section Abstract Doc Link 1982111 Disease Relevance 0 Pain Relevance 0.30
In control animals, piperoxane increases LC neuronal firing showing that these noradrenergic neurones are under alpha 2-adrenoceptor-mediated tonic inhibition.
Negative_regulation (inhibition) of alpha 2-adrenoceptor-mediated in neuronal associated with locus ceruleus
6) Confidence 0.43 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990957 Disease Relevance 0 Pain Relevance 0.46
The alpha 2-adrenoceptor agonists, UK 14,304, xylazine, B-HT 933, B-HT 920, clonidine and M-7, produced concentration-dependent prejunctional alpha 2-adrenoceptor-mediated inhibition of neurogenic responses in the guinea pig atrium and rat vas deferens and produced postjunctional alpha 2-adrenoceptor-mediated contraction of the canine saphenous vein.
Negative_regulation (inhibition) of alpha 2-adrenoceptor-mediated in atrium associated with agonist and clonidine
7) Confidence 0.43 Published 1991 Journal Pharmacology Section Abstract Doc Link 1683709 Disease Relevance 0 Pain Relevance 0.37
The effect of alpha2-adrenoceptor blockade in the medulla was studied in pentobarbital anesthetized rats in which arterial blood pressure, heart rate and renal sympathetic nerve activity were analysed.
Negative_regulation (blockade) of alpha2-adrenoceptor in medulla associated with medulla
8) Confidence 0.43 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12398917 Disease Relevance 0 Pain Relevance 0.15
Effects of medullary alpha2-adrenoceptor blockade in the rat.
Negative_regulation (blockade) of alpha2-adrenoceptor
9) Confidence 0.43 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12398917 Disease Relevance 0.07 Pain Relevance 0.31
Can the alpha 2-adrenoceptor agonist-mediated suppression of nocifensive reflex responses be due to action on motoneurons or peripheral nociceptors?
Negative_regulation (suppression) of alpha 2-adrenoceptor in nociceptors associated with nociceptor and agonist
10) Confidence 0.43 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7501249 Disease Relevance 0 Pain Relevance 0.62
These results suggest that inhaled anesthetics decrease the number of alpha 2-adrenergic receptors.
Negative_regulation (decrease) of alpha 2-adrenergic
11) Confidence 0.43 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8380957 Disease Relevance 0.48 Pain Relevance 0.71
Both halothane and isoflurane decreased alpha 2-adrenergic receptor density 20% compared to unanesthetized values (P < 0.01).
Negative_regulation (decreased) of alpha 2-adrenergic associated with isoflurane and halothane
12) Confidence 0.43 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8380957 Disease Relevance 0.53 Pain Relevance 0.76
Chronic cocaine reduces alpha 2-adrenoceptor elicited mydriasis and inhibition of locus coeruleus neurons.
Negative_regulation (reduces) of alpha 2-adrenoceptor in neurons associated with mydriatic, locus ceruleus and cocaine
13) Confidence 0.43 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2547625 Disease Relevance 0.25 Pain Relevance 0.63
Blockade of alpha2-adrenergic receptors with intravenous doses of SKF 86466 (200 microg kg(-1)) abolished all respiratory effects of the clonidine challenge.
Negative_regulation (Blockade) of alpha2-adrenergic in respiratory associated with clonidine
14) Confidence 0.42 Published 2006 Journal Exp. Physiol. Section Abstract Doc Link 16282369 Disease Relevance 0 Pain Relevance 0.59
Tramadol-induced downregulation of alpha2-adrenergic receptors--when combined with ongoing antidepressant therapy with drugs, which themselves inhibit serotonin reuptake or are antagonists of alpha2-adrenergic receptors--might cause threatening complications.
Negative_regulation (downregulation) of alpha2-adrenergic associated with tramadol, antidepressant, antagonist and serotonin
15) Confidence 0.42 Published 2004 Journal Brain Res. Section Abstract Doc Link 15246863 Disease Relevance 0.10 Pain Relevance 1.04
Coadministration of maprotiline increased the antinociceptive duration of morphine by 4-fold (from 120 to 480 min), which was reversed by pretreatment with the alpha-2 adrenoceptor inhibitor, yohimbine, and the mu-type opioid receptor antagonist, naloxone.
Negative_regulation (inhibitor) of alpha-2 adrenoceptor
16) Confidence 0.42 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19762762 Disease Relevance 0 Pain Relevance 0
A procedure for measuring alpha 2-adrenergic receptor-mediated inhibition of cyclic AMP accumulation in rat brain slices.
Negative_regulation (inhibition) of alpha 2-adrenergic in brain associated with adenocard
17) Confidence 0.41 Published 1986 Journal Brain Res. Section Title Doc Link 3022868 Disease Relevance 0 Pain Relevance 0.49
However, unilateral microinjection of idazoxan (a mixed antagonist of imidazoline receptor and alpha2-adrenoceptor, 2 nmol/50 nl) into the caudal ventrolateral medulla significantly (P<0.01) decreased mean arterial pressure, heart rate, and the discharge of the rostral ventrolateral medulla presympathetic neurons, and completely abolished the pressor effect of clonidine.
Negative_regulation (antagonist) of alpha2-adrenoceptor in medulla associated with medulla, rostral ventrolateral medulla, antagonist and clonidine
18) Confidence 0.40 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 12827019 Disease Relevance 0.08 Pain Relevance 1.08
We observed a decrease in alpha2A-adrenergic receptor immunoreactivity in the spinal cord ipsilateral to three models of neuropathic pain: complete sciatic nerve transection, chronic constriction injury of the sciatic nerve and L5/L6 spinal nerve ligation.
Negative_regulation (decrease) of alpha2A-adrenergic in sciatic nerve associated with eae, injury, neuropathic pain, sciatic nerve and spinal cord
19) Confidence 0.38 Published 1999 Journal Neuroscience Section Abstract Doc Link 10501465 Disease Relevance 1.07 Pain Relevance 0.98
The decrease in alpha2A-adrenergic receptor immunoreactivity and the lack of consistent changes in alpha2C-adrenergic receptor immunoreactivity suggest that neither of these receptor subtypes is likely to be responsible for the abnormal adrenergic sensitivity observed following nerve injury.
Negative_regulation (decrease) of alpha2A-adrenergic in nerve associated with nervous system injury
20) Confidence 0.38 Published 1999 Journal Neuroscience Section Abstract Doc Link 10501465 Disease Relevance 0.72 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox