INT77790

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 15.88
Pain Relevance 8.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
neuronal 6
DRG 6
macrophages 2
retina 2
neurons 2
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 278 100.00 Very High Very High Very High
Arthritis 127 99.96 Very High Very High Very High
Dorsal horn 208 99.84 Very High Very High Very High
Dorsal horn neuron 26 99.84 Very High Very High Very High
Inflammation 316 99.60 Very High Very High Very High
Hyperalgesia 150 98.64 Very High Very High Very High
Glutamate 14 98.56 Very High Very High Very High
spinal dorsal horn 3 98.42 Very High Very High Very High
withdrawal 37 92.64 High High
Snapping jaw 6 92.28 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 279 100.00 Very High Very High Very High
Apoptosis 97 100.00 Very High Very High Very High
Arthritis 157 99.96 Very High Very High Very High
INFLAMMATION 315 99.60 Very High Very High Very High
Nervous System Injury 236 99.56 Very High Very High Very High
Sepsis 50 99.48 Very High Very High Very High
Injury 140 99.34 Very High Very High Very High
Neuropathic Pain 102 99.12 Very High Very High Very High
Death 46 98.94 Very High Very High Very High
Hyperalgesia 204 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been previously shown that TNFR1 expression is upregulated following nerve injury and parallels the display of nociceptive behavior.
Positive_regulation (upregulated) of Gene_expression (expression) of TNFR1 in nerve associated with nociception and nervous system injury
1) Confidence 0.67 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.86 Pain Relevance 0.36
Previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor 1 (TNFR1) in dorsal root ganglia (DRG) and in spinal dorsal horn are upregulated after nerve injury and that many TNF-alpha-containing neurons overexpress TNFR1.
Positive_regulation (overexpress) of Gene_expression (overexpress) of TNFR1 in dorsal root ganglia associated with necrosis, nervous system injury, cancer and spinal dorsal horn
2) Confidence 0.62 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.45 Pain Relevance 0.25
Recently, increased neuronal TNFR1 expression was reported in association with intraperitoneal lipopolysaccharide [13], suggesting a direct TNF effect on nociceptive pathways via TNFR1.
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 in neuronal associated with nociception
3) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.95 Pain Relevance 0.67
The observation that neuronal expression of neuronal TNFR1 increased with time confirms and extends previous observations made in neuropathic models [15,13].
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 in neuronal associated with neuropathic pain
4) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.22 Pain Relevance 0.88
Since TNFR1 expression is also increased in dorsal horn neurons after nerve injury [12], an upregulation of TNFR1 and subsequent increase in glutamate release probability at the presynaptic terminals of excitatory interneurons may also contribute to the increased mEPSC rate.
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 in neurons associated with glutamate, nervous system injury and dorsal horn neuron
5) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.39 Pain Relevance 0.48
Thus, an increase in TNFR1 expression in SDH neurons under neuropathic conditions could increase the number of functional synapses via AMPAR insertion into the postsynaptic membrane and thus potentiate glutamatergic signaling.
Positive_regulation (increase) of Gene_expression (expression) of TNFR1 in postsynaptic membrane associated with neuropathic pain and dorsal horn
6) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.10 Pain Relevance 0.26
Enhanced expression of TNF-R1 protein in NMDA-mediated cell death in the retina.
Positive_regulation (Enhanced) of Gene_expression (expression) of TNF-R1 in retina associated with death
7) Confidence 0.49 Published 2002 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12531535 Disease Relevance 0.25 Pain Relevance 0.08
Since the TNFR is an essential element in the TNF?
Positive_regulation (Since) of Gene_expression (is) of TNFR
8) Confidence 0.44 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.19 Pain Relevance 0.05
After induction of CFA arthritis, expression of both TNFR1 and TNFR2 within the DRG tissues was markedly increased.
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 associated with dorsal root ganglion and arthritis
9) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.27 Pain Relevance 0.91
Inflammation is associated with increased TNFR1 expression by neuronal cells, potentially leading to direct activation of these cells by TNF under inflammatory conditions.
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 in neuronal associated with inflammation
10) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 2.42 Pain Relevance 1.14
TNFR1 expression was increased in neuronal cells of the DRG bilaterally after arthritis induction.
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 in DRG associated with dorsal root ganglion and arthritis
11) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175031 Disease Relevance 1.94 Pain Relevance 1.18
Joint inflammation was associated with increased TNFR1 and TNFR2 expression on DRG cells, which was maintained throughout the time course of the model.
Positive_regulation (increased) of Gene_expression (expression) of TNFR1 in DRG associated with dorsal root ganglion, inflammation and arthritis
12) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175031 Disease Relevance 1.94 Pain Relevance 1.18
Concentrations of TNF-alpha, TNF-R1, caspase-3 and -8, and apoptosis were significantly elevated in CFA-injected animals compared to uninjected controls.
Positive_regulation (elevated) of Gene_expression (Concentrations) of TNF-R1 associated with apoptosis
13) Confidence 0.18 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 14596872 Disease Relevance 1.46 Pain Relevance 0.67
An acute exposure to LPS led to a marked increase in the expression of TNFR1 by BALF macrophages (by ~47-fold, P<0.001 vs. control).
Positive_regulation (increase) of Gene_expression (expression) of TNFR1 in macrophages
14) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0.13 Pain Relevance 0
Since increased AICD with thermal injury/sepsis could also be related to increased expressions of receptors Fas and TNFR, their surface expressions was assessed using anti-Fas and anti-TNFR antibodies and FACS analyses.
Positive_regulation (increased) of Gene_expression (expressions) of TNFR associated with injury, sepsis and death
15) Confidence 0.09 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.56 Pain Relevance 0.07
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of p55
16) Confidence 0.02 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.76 Pain Relevance 0.34

General Comments

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