INT77792

Context Info Confidence 0.04 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.82 Pain Relevance 0.32

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) transferase activity, transferring glycosyl groups (fut10) Golgi apparatus (fut10) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)

Anatomy Link Frequency Schwann cell 2 fut10 (Rattus norvegicus) Tnfrsf1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hyperalgesia 4 91.76 cytokine 1 56.56

Disease Link Frequency Relevance Heat Nociception 2 100.00 Hyperalgesia 4 91.76 Nervous System Injury 3 86.92 Necrosis 1 57.16 Cancer 1 56.80 Nerve Degeneration 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that TX14(A) decreased nociceptive behavior by attenuating both TNFR1 upregulation and Schwann cell activation in response to TNF injection.

TX14 Negative_regulation (attenuating) of Positive_regulation (upregulation) of TNFR1 in Schwann cell associated with nociception

1) Confidence 0.04 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.82 Pain Relevance 0.32

General Comments

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