INT77794

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 8.38
Pain Relevance 8.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
glial cell 2
neurons 2
outflow 1
spinal cord 1
neural 1
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 8 100.00 Very High Very High Very High
Glial derived neurotrophic factor 1 100.00 Very High Very High Very High
intrathecal 5 99.98 Very High Very High Very High
Nerve growth factor 509 99.96 Very High Very High Very High
Calcitonin gene-related peptide 480 99.44 Very High Very High Very High
Hyperalgesia 60 99.44 Very High Very High Very High
c fibre 5 99.28 Very High Very High Very High
Spinal cord 83 99.20 Very High Very High Very High
Pain 64 99.16 Very High Very High Very High
qutenza 260 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Frailty 9 99.48 Very High Very High Very High
Hyperalgesia 80 99.44 Very High Very High Very High
Injury 280 99.20 Very High Very High Very High
Pain 62 99.16 Very High Very High Very High
Ganglion Cysts 373 98.24 Very High Very High Very High
INFLAMMATION 40 96.52 Very High Very High Very High
Nociception 107 95.72 Very High Very High Very High
Adhesions 2 95.48 Very High Very High Very High
Inflammatory Pain 1 93.64 High High
Pressure And Volume Under Development 10 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that GDNF is well associated with nonpeptidergic pain pathway and that GDNF could possibly be anterogradely transported from DRG neurons to superficial spinal cord dorsal horn.
GDNF Binding (associated) of in DRG associated with pain, dorsal horn and spinal cord
1) Confidence 0.48 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 0.84 Pain Relevance 0.92
Signals of hybridization for GDNF mRNA were markedly detected in the Central canal and lamina III, IV and V, in which small neurons were moderately NBT/BCIP stained (Fig. 5a).
GDNF mRNA Binding (hybridization) of in neurons
2) Confidence 0.37 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.08
However, a combination of BDNF and GDNF (but not with NT-3 or NGF) given either 60 or 90 min after SCI significantly reduced the motor dysfunction and spinal cord pathology at 5 h.
GDNF Neg (not) Binding (combination) of in spinal cord associated with frailty and spinal cord
3) Confidence 0.36 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077567 Disease Relevance 1.14 Pain Relevance 0.40
At both 14 and 21 dpo, astrocytes in the white matter strongly stain with GDNF immunoreactivity as shown in Fig. 4f, h and Table 2.


GDNF Binding (stain) of in white matter
4) Confidence 0.32 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.07
After dorsal root transection GDNF disappeared from the dorsal horn and after dorsal root ligation there was accumulation of GDNF only on the ganglion side of the ligation.
GDNF Binding (ligation) of in ganglion associated with ganglion cysts and dorsal horn
5) Confidence 0.31 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760141 Disease Relevance 0.20 Pain Relevance 0.37
Recombinant human glial cell line-derived neurotrophic factor (rhGDNF) is a 30 kDa homodimer consisting of two disulfide-linked 134 amino acid subunits.
glial cell line-derived neurotrophic factor Binding (homodimer) of in glial cell
6) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.45 Pain Relevance 0.15
Recombinant human glial cell line-derived neurotrophic factor (rhGDNF) is a 30 kDa homodimer consisting of two disulfide-linked 134 amino acid subunits.
rhGDNF Binding (homodimer) of in glial cell
7) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.39 Pain Relevance 0.15
Glial cell line-derived neurotrophic factor (GDNF) has a variety of functions affecting the survival and development of specified neural cell populations, mediated via transmission of intracellular signals through binding to its high-affinity receptor, GFR*1, and subsequent activation of a tyrosine receptor kinase, RET, neural cell adhesion molecule (NCAM), or other signaling molecules.
GDNF Binding (binding) of in neural associated with adhesions
8) Confidence 0.26 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 0.77 Pain Relevance 0.89
GDNF binds most readily to GFR alpha-1, but also binds to GFR alpha-2 / c-ret heterodimers [50].
GDNF Binding (binds) of
9) Confidence 0.24 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.52 Pain Relevance 0.71
QuAM elucidates these NGF/GDNF and EGF signalling differences and explains thereby the contrary behavior of these in inflammation physiological relevant growth factors.
GDNF Binding (elucidates) of associated with inflammation
10) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.58 Pain Relevance 0.48
The receptor for GDNF is a complex of a ligand binding domain GFR1-3 and the signal transducing transmembrane protein, RET, and is expressed in a subgroup of non-peptidergic (IB4(+)) neurons [16].
GDNF Binding (binding) of in neurons
11) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0.03
Intradermal injection of NGF and GDNF induces strong hyperalgesia as measured by the Randall-Selitto paw pressure test [19,22].
GDNF Binding (injection) of in paw associated with hyperalgesia
12) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.61 Pain Relevance 0.50
GDNF binds most readily to GFR alpha-1, but also binds to GFR alpha-2 / c-ret heterodimers [50].
GDNF Binding (binds) of
13) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.52 Pain Relevance 0.71
On the other hand, intrathecal injection of GDNF has no effect on C-fiber evoked outflow of SP and does not induce thermal hyperalgesia, while NGF does both [15].
GDNF Binding (injection) of in outflow associated with c fibre, nerve growth factor, thermal hyperalgesia, substance p and intrathecal
14) Confidence 0.16 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.98 Pain Relevance 1.63
Effects of NGF, GDNF or BDNF treatment on K+-evoked CGRP release and CGRP content
GDNF Binding (treatment) of associated with nerve growth factor and calcitonin gene-related peptide
15) Confidence 0.16 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.14 Pain Relevance 0.71
Effects of NGF, GDNF or BDNF treatment on TRPV1 mRNA and protein levels
GDNF Binding (treatment) of associated with nerve growth factor
16) Confidence 0.16 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.33 Pain Relevance 0.39
The RET protein is a subunit of a multimolecular complex that binds growth factors of the glial derived neurotrophic factor (GDNF) family.
GDNF Binding (binds) of associated with glial derived neurotrophic factor
17) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.90 Pain Relevance 0.05

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