INT77795

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Context Info
Confidence 0.81
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 6.29
Pain Relevance 8.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
white matter 4
spinal cord 2
spinal 2
IB4 1
dorsal horn 1
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 151 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Spinal cord 283 99.84 Very High Very High Very High
Endep 42 99.82 Very High Very High Very High
fluoxetine 6 99.18 Very High Very High Very High
antidepressant 48 98.80 Very High Very High Very High
withdrawal 12 98.80 Very High Very High Very High
Dorsal horn 20 98.56 Very High Very High Very High
qutenza 57 98.50 Very High Very High Very High
Sciatic nerve 4 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 36 99.76 Very High Very High Very High
Cicatrix 74 99.60 Very High Very High Very High
Glioblastoma 12 99.56 Very High Very High Very High
Disease 40 98.96 Very High Very High Very High
Injury 399 96.96 Very High Very High Very High
Ganglion Cysts 79 96.86 Very High Very High Very High
Cancer 17 95.24 Very High Very High Very High
Pain 20 94.64 High High
Neuropathic Pain 6 93.76 High High
Hyperalgesia 22 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical localization of GDNF in primary afferents of the lumbar dorsal horn.
Localization (localization) of GDNF in dorsal horn associated with dorsal horn
1) Confidence 0.81 Published 1998 Journal Neuroreport Section Title Doc Link 9760141 Disease Relevance 0.17 Pain Relevance 0.35
The subcellular localization for GDNF was observed both in cytoplasm and nuclei at 21 dpo (Fig. 4g).
Localization (localization) of GDNF
2) Confidence 0.80 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.07
Localization of GDNF mRNA in spinal cord of rats
Localization (Localization) of GDNF mRNA in spinal cord associated with spinal cord
3) Confidence 0.80 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.08
Here, we demonstrated that long-term use of antidepressant treatment significantly increased GDNF mRNA expression and GDNF release in time- and concentration-dependent manners in rat C6 glioblastoma cells.
Localization (release) of GDNF associated with antidepressant and glioblastoma
4) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.51
GDNF release continued for 24 h following withdrawal of amitriptyline.
Localization (release) of GDNF associated with endep and withdrawal
5) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.56
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Localization (release) of GDNF associated with endep and kinase c inhibitor
6) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.15 Pain Relevance 0.65
Furthermore, following treatment with antidepressants belonging to several different classes (amitriptyline, clomipramine, mianserin, fluoxetine and paroxetine) significantly increased GDNF release, but which did not occur after treatment with non-antidepressant psychotropic drugs (haloperidol, diazepam and diphenhydramine).
Localization (release) of GDNF associated with antidepressant, endep and fluoxetine
7) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.16 Pain Relevance 0.64
These results suggested that amitriptyline-induced GDNF synthesis and release occurred at the transcriptional level, and may be regulated by MEK/MAPK signalling.
Localization (release) of GDNF associated with endep
8) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.14 Pain Relevance 0.60
Under higher magnification, immunoreactive structures of GDNF were localized in both cytoplasm and nuclei at 21 dpo (g, 400×, arrow), GDNF IR in astrocytes of the white matter was intensely immunostained at 14 and 21 dpo (f, h, 400×, arrows)
Localization (localized) of GDNF in white matter
9) Confidence 0.70 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.06
Under higher magnification, immunoreactive structures of GDNF were localized in both cytoplasm and nuclei at 21 dpo (g, 400×, arrow), GDNF IR in astrocytes of the white matter was intensely immunostained at 14 and 21 dpo (f, h, 400×, arrows)
Localization (localized) of GDNF in white matter
10) Confidence 0.70 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.06
Under higher magnification, immunoreactive structures of GDNF were localized in both cytoplasm and nuclei at 21 dpo (g, 400×, arrow), GDNF IR in astrocytes of the white matter was intensely immunostained at 14 and 21 dpo (f, h, 400×, arrows)
Localization (localized) of GDNF in white matter
11) Confidence 0.70 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.06
Under higher magnification, immunoreactive structures of GDNF were localized in both cytoplasm and nuclei at 21 dpo (g, 400×, arrow), GDNF IR in astrocytes of the white matter was intensely immunostained at 14 and 21 dpo (f, h, 400×, arrows)
Localization (localized) of GDNF in white matter
12) Confidence 0.70 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.06
GDNF antibody neutralization
Localization (neutralization) of GDNF
13) Confidence 0.65 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.18 Pain Relevance 0.04
Second, GDNF is metabolized quickly after it is injected into the body.
Localization (metabolized) of GDNF in body
14) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.86 Pain Relevance 0
Accompanied by the behavioral changes, expression of GDNF decreased in the dorsal root ganglia (DRGs) and the sciatic nerve on the injured side on the fourteenth day after the surgery.
Localization (decreased) of GDNF in DRGs associated with sciatic nerve
15) Confidence 0.63 Published 2003 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12715924 Disease Relevance 0.54 Pain Relevance 0.70
To localize GDNF protein in the spinal cord, an affinity-purified rabbit polyclonal antibody (D-20, Santa Cruz Biotechnology, Santa Cruz, CA, USA) was used in this study.
Localization (localize) of GDNF in spinal cord associated with spinal cord
16) Confidence 0.61 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.25 Pain Relevance 0.26
We further suggest that the endogenous release of GDNF and BDNF, triggered by nociceptive stimuli, is involved in the induction of changes in spinal nociceptive transmission as in various pain states.
Localization (release) of GDNF in spinal associated with nociception and pain
17) Confidence 0.61 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899262 Disease Relevance 0.45 Pain Relevance 0.46
Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells.
Localization (release) of GDNF in glial cell associated with antidepressant and glioblastoma
18) Confidence 0.60 Published 2001 Journal J. Neurochem. Section Title Doc Link 11595754 Disease Relevance 0.18 Pain Relevance 0.59
This role may include mediating the effects of GDNF released from nociceptive afferent fibers.
Localization (released) of GDNF associated with nociception
19) Confidence 0.56 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17183535 Disease Relevance 0.43 Pain Relevance 0.33
Nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) regulate substance P release in adult spinal sensory neurons.
Localization (release) of GDNF in spinal associated with nerve growth factor and substance p
20) Confidence 0.47 Published 2003 Journal Neurochem. Res. Section Title Doc Link 12718437 Disease Relevance 0 Pain Relevance 0.92

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