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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
brain 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Delta opioid receptors 1 98.64 Very High Very High Very High
tramadol 8 98.48 Very High Very High Very High
antagonist 7 97.92 Very High Very High Very High
Endogenous opioid 2 94.00 High High
Kappa opioid receptor 1 90.00 High High
Nucleus accumbens 1 89.92 High High
antidepressant 5 87.76 High High
Thalamus 1 87.52 High High
Pain 1 85.84 High High
amygdala 1 85.60 High High
Disease Link Frequency Relevance Heat
Pain 2 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tramadol (20 mg/kg, i.p.) administered acutely (single dose), at 24 h after dosing, induced a significant decrease in the alpha2-adrenergic receptors in all brain regions studied.
Positive_regulation (induced) of Negative_regulation (decrease) of alpha2-adrenergic in brain associated with tramadol
1) Confidence 0.50 Published 2004 Journal Brain Res. Section Abstract Doc Link 15246863 Disease Relevance 0.09 Pain Relevance 0.76
This response is unlikely to be due to alpha 2-adrenoceptor blockade, since other highly selective alpha 2-adrenoceptor antagonists do not increase food intake and, instead may reflect the high affinity of idazoxan for non-adrenoceptor idazoxan binding sites.
Positive_regulation (due) of Negative_regulation (blockade) of alpha 2-adrenoceptor associated with antagonist
2) Confidence 0.42 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1356252 Disease Relevance 0 Pain Relevance 0.72

General Comments

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