INT77801

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 3.93
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
liver 2
neutrophils 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 7 99.88 Very High Very High Very High
Angina 3 99.00 Very High Very High Very High
COX2 29 98.88 Very High Very High Very High
Inflammation 31 98.20 Very High Very High Very High
Peripheral nerve injury 6 97.36 Very High Very High Very High
Sciatic nerve 10 89.92 High High
cytokine 21 75.00 Quite High
Inflammatory mediators 10 69.96 Quite High
allodynia 39 50.00 Quite Low
Pain 17 43.84 Quite Low
Disease Link Frequency Relevance Heat
Cancer 24 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Immunization 1 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 6 99.88 Very High Very High Very High
Appetite Loss 23 99.76 Very High Very High Very High
Stomach Cancer 13 99.58 Very High Very High Very High
Stable Angina Pectoris 3 99.28 Very High Very High Very High
Hepatotoxicity 3 98.36 Very High Very High Very High
INFLAMMATION 43 98.20 Very High Very High Very High
Nervous System Injury 12 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Focal liver necrosis, which had been observed in earlier studies after antigen therapy in AT-EAN, was prevented by passive immunization with neutralizing anti-TNF-alpha antibody.
Negative_regulation (prevented) of TNF-alpha Binding (immunization) of in liver associated with immunization, hepatotoxicity and neuritis
1) Confidence 0.42 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10888366 Disease Relevance 1.44 Pain Relevance 0.68
SB203580 treatment significantly reduced the immunoreactivity of iNOS, TNF-?
Negative_regulation (reduced) of TNF Binding (immunoreactivity) of
2) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.22 Pain Relevance 0.41
COX-2: cyclooxygenase-2; SFI: sciatic functional index; CLX: celecoxib; TNF-alpha: tumour necrosis factor alpha; NF-kappaB: nuclear factor kappa b; SD: standard deviation.


Negative_regulation (necrosis) of TNF-alpha Binding (index) of associated with necrosis and cancer
3) Confidence 0.26 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.92 Pain Relevance 0.33
[The effect of pentoxifylline on oxidative metabolism in neutrophils primed with tumor necrosis factor alpha in patients with stable angina pectoris].
Negative_regulation (metabolism) of tumor necrosis factor alpha Binding (primed) of in neutrophils associated with stable angina pectoris, necrosis, angina and cancer
4) Confidence 0.24 Published 1998 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 9760817 Disease Relevance 0.49 Pain Relevance 0.29
A Randomized Pilot Study of Atractylenolide I on Gastric Cancer Cachexia Patients

We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-?)

Negative_regulation (interpreted) of tumor necrosis factor alpha Binding (investigating) of associated with appetite loss, necrosis, cancer and stomach cancer
5) Confidence 0.07 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Title Doc Link PMC2529387 Disease Relevance 0.86 Pain Relevance 0.06

General Comments

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