INT77804

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Context Info
Confidence 0.39
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.71
Pain Relevance 7.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
muscles 2
macrophages 1
sympathetic nervous system 1
granule cells 1
Ednra (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
analgesia 19 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
Clonidine 28 99.96 Very High Very High Very High
COX2 18 98.94 Very High Very High Very High
Inflammation 15 98.76 Very High Very High Very High
Action potential 28 98.52 Very High Very High Very High
Analgesic 13 98.20 Very High Very High Very High
Hyperalgesia 8 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.12 Very High Very High Very High
Cancer 51 98.96 Very High Very High Very High
Hyperalgesia 9 97.60 Very High Very High Very High
Constipation 1 97.04 Very High Very High Very High
Pain 4 93.36 High High
Drug Induced Neurotoxicity 2 90.16 High High
Neuropathic Pain 1 89.24 High High
Arrhythmias 2 Under Development 2 85.60 High High
Cv General 4 Under Development 4 85.04 High High
Increased Venous Pressure Under Development 14 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelin ETA receptor blockade potentiates morphine analgesia but does not affect gastrointestinal transit in mice.
Neg (not) Regulation (affect) of Endothelin ETA receptor associated with pain, analgesia and morphine
1) Confidence 0.39 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16814278 Disease Relevance 0.19 Pain Relevance 1.59
The effect of another ETA receptor antagonist, BMS-182874 (2, 10, and 50 microg, i.c.v.) was studied, and it was found that the dose of 10 microg significantly potentiated (26% increase in AUC) the analgesic effect of clonidine.
Regulation (effect) of ETA receptor associated with analgesic, antagonist and clonidine
2) Confidence 0.36 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 20555423 Disease Relevance 0.08 Pain Relevance 2.39
Clonidine and ET have been reported to have cardiovascular interactions involving the sympathetic nervous system, but it is not known whether ETA receptor antagonist affects clonidine analgesia.
Spec (whether) Regulation (affects) of ETA receptor in sympathetic nervous system associated with antagonist, analgesia and clonidine
3) Confidence 0.36 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 20555423 Disease Relevance 0.06 Pain Relevance 1.77
We have studied the effect of ETA and ETB receptor antagonists in the thermal and mechanical hyperalgesia induced in a model of acute (induced by carrageenan) and chronic (induced by complete Freund's adjuvant, CFA) inflammation in mice.
Regulation (effect) of ETA associated with hyperalgesia, inflammation and antagonist
4) Confidence 0.36 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14661069 Disease Relevance 1.09 Pain Relevance 0.86
We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.
Neg (without) Regulation (involving) of ET in macrophages associated with cox2
5) Confidence 0.28 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.06 Pain Relevance 0.54
In the present study, we examined the effects of endothelin-1 on cyclooxygenase 2 expression and prostaglandin E2 production, and the effects of endothelin ET(A) and ET(B) receptor antagonists.
Regulation (effects) of ET associated with antagonist and cox2
6) Confidence 0.15 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.59 Pain Relevance 0.66
In the ETA, in muscles up to 36 days after BoNT/A, we observed a value of 0.17 m s?
Regulation (value) of ETA in muscles
7) Confidence 0.05 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0
In control ETA muscles these have a mean amplitude of 1.92 mV (s.d. 0.48 mV, n = 10).
Regulation (control) of ETA in muscles
8) Confidence 0.05 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.09 Pain Relevance 0.05
The above immunostaining data and our electrophysiological findings clearly pinpoint the granule cells of the cerebellar cortex as a major ET target.
Regulation (target) of ET in granule cells
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.08
Previous experimental work in various rodent models provided evidence for efficacy of the recombinant antibody toxin scFv(FRP5)-ETA against ErbB2-expressing tumors [9,10,14,16,18,19].
Regulation (efficacy) of ETA associated with cancer
10) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.55 Pain Relevance 0

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