INT77805

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Context Info
Confidence 0.51
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Title
Documents 6
Total Number 9
Disease Relevance 2.70
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 2
microglial cells 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 15 100.00 Very High Very High Very High
cINOD 7 100.00 Very High Very High Very High
antagonist 155 99.84 Very High Very High Very High
Inflammation 29 97.80 Very High Very High Very High
Potency 1 94.80 High High
headache 1 94.52 High High
Analgesic 1 89.32 High High
dexamethasone 1 80.76 Quite High
cOX1 1 78.52 Quite High
cva 1 52.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 42 100.00 Very High Very High Very High
Nasopharynx Cancer 4 99.76 Very High Very High Very High
Reprotox - General 1 10 99.52 Very High Very High Very High
Adenocarcinoma 30 97.56 Very High Very High Very High
Adhesions 2 96.68 Very High Very High Very High
Headache 1 94.52 High High
Cancer 28 93.28 High High
Infection 41 87.88 High High
Endometriosis (extended) 24 87.68 High High
Drug Induced Neurotoxicity 1 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelin ET(A) and ET(B) receptor antagonists had no effects on cyclooxygenase 2 protein expression and prostaglandin E2 production in lipopolysaccharide-stimulated macrophages.
Neg (no) Regulation (effects) of Gene_expression (expression) of cyclooxygenase 2 protein in macrophages associated with antagonist and cox2
1) Confidence 0.51 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.40 Pain Relevance 0.84
Inhibitory effect of Angelicae Tenuissimae Radix on expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells.
Regulation (effect) of Gene_expression (expressions) of cyclooxygenase-2 in microglial cells associated with cox2
2) Confidence 0.45 Published 2010 Journal Neurol. Res. Section Title Doc Link 20034447 Disease Relevance 0.09 Pain Relevance 0.32
OBJECTIVE: To explore the effects of nonsteroidal anti-inflammatory drug Celecoxib on the expression of cyclooxygenase-2 (COX-2) in the SKOV3 cell line and the xenografted nude mice of ovarian carcinoma.
Regulation (effects) of Gene_expression (expression) of cyclooxygenase-2 associated with inflammation, cinod and reprotox - general 1
3) Confidence 0.42 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 17037745 Disease Relevance 0.35 Pain Relevance 0.17
[Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma cell].
Regulation ([Effects) of Gene_expression (expression) of cyclooxygenase-2 associated with inflammation, cinod, cox2 and reprotox - general 1
4) Confidence 0.30 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 17037745 Disease Relevance 0.30 Pain Relevance 0.30
The mean change in expression level of Cox1 (Ptgs1) and Cox2 (Ptgs2), and a selection of Cox2-dependent genes involved in inflammation (intracellular adhesion molecule 1, Icam1; Transforming growth factor b1,Tgfb1), gastric function (Gastrin, Gast), barrier function (Aquaporin 5, Aqp5; Tight junction protein 1, Tjp1) and proliferation/carcinogenesis (Ornithine decarboxylase, Odc1) was determined for individual mice at all time points by real-time PCR (Additional File 1, Table S4).
Spec (determined) Regulation (change) of Gene_expression (expression) of Ptgs2 associated with inflammation and adhesions
5) Confidence 0.20 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.45 Pain Relevance 0.10
Celecoxib induces dose dependent growth inhibition in nasopharyngeal carcinoma cell lines independent of cyclooxygenase-2 expression.
Neg (independent) Regulation (independent) of Gene_expression (expression) of cyclooxygenase-2 associated with nasopharynx cancer and cox2
6) Confidence 0.02 Published 2005 Journal Biomed. Pharmacother. Section Title Doc Link 16507390 Disease Relevance 0.56 Pain Relevance 0.19
activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
Regulation (-) of Gene_expression (expression) of cyclooxygenase-2
7) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Title Doc Link PMC2694994 Disease Relevance 0.19 Pain Relevance 0
activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
Regulation (regulate) of Gene_expression (expression) of cyclooxygenase-2
8) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Title Doc Link PMC2694994 Disease Relevance 0.19 Pain Relevance 0
activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
Regulation (up) of Gene_expression (expression) of cyclooxygenase-2
9) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Title Doc Link PMC2694994 Disease Relevance 0.19 Pain Relevance 0

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