INT77806

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.24
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Edn1, Ptgs2) endoplasmic reticulum (Ptgs2) enzyme binding (Ptgs2)
protein complex (Ptgs2) cell-cell signaling (Edn1) lipid binding (Ptgs2)
Anatomy Link Frequency
macrophages 2
Edn1 (Mus musculus)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 18 100.00 Very High Very High Very High
Inflammation 4 97.20 Very High Very High Very High
antagonist 10 96.44 Very High Very High Very High
cva 2 93.00 High High
ischemia 2 91.28 High High
cOX1 2 75.52 Quite High
dexamethasone 2 70.80 Quite High
cINOD 2 69.60 Quite High
Potency 2 42.24 Quite Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 2 98.12 Very High Very High Very High
INFLAMMATION 6 97.20 Very High Very High Very High
Cv General 4 Under Development 4 93.00 High High
Increased Venous Pressure Under Development 2 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined the effects of endothelin-1 on cyclooxygenase 2 expression and prostaglandin E2 production, and the effects of endothelin ET(A) and ET(B) receptor antagonists.
endothelin Spec (examined) Regulation (effects) of Gene_expression (expression) of cyclooxygenase 2 associated with antagonist and cox2
1) Confidence 0.29 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.61 Pain Relevance 0.62
However, it has not yet been established how endothelin-1 acts on cyclooxygenase 2 expression in macrophages.
endothelin Regulation (acts) of Gene_expression (expression) of cyclooxygenase 2 in macrophages associated with cox2
2) Confidence 0.29 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.63 Pain Relevance 0.60

General Comments

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