INT77807

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.53
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Edn1, Ptgs2) endoplasmic reticulum (Ptgs2) enzyme binding (Ptgs2)
protein complex (Ptgs2) cell-cell signaling (Edn1) lipid binding (Ptgs2)
Anatomy Link Frequency
macrophages 6
Edn1 (Mus musculus)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 27 100.00 Very High Very High Very High
antagonist 15 94.00 High High
Potency 3 89.12 High High
cINOD 3 76.60 Quite High
dexamethasone 3 75.08 Quite High
cOX1 3 72.84 Quite High
Inflammation 6 50.88 Quite High
cva 3 46.68 Quite Low
ischemia 3 44.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 76.36 Quite High
Drug Induced Neurotoxicity 3 51.80 Quite High
Cv General 4 Under Development 6 46.68 Quite Low
Increased Venous Pressure Under Development 3 45.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.
endothelin Positive_regulation (increases) of Gene_expression (expression) of cyclooxygenase 2 protein in macrophages associated with cox2
1) Confidence 0.33 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.18 Pain Relevance 0.70
We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.
endothelin Positive_regulation (increases) of Gene_expression (expression) of cyclooxygenase 2 protein in macrophages associated with cox2
2) Confidence 0.24 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.18 Pain Relevance 0.70
We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.
endothelin Positive_regulation (increases) of Gene_expression (expression) of cyclooxygenase 2 protein in macrophages associated with cox2
3) Confidence 0.21 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.18 Pain Relevance 0.70

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox