INT77809

Context Info Confidence 0.65 First Reported 1998 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.35 Pain Relevance 1.24

cytosol (NUP214) nucleoplasm (NUP214) small molecule metabolic process (NUP214) nucleus (NUP214) carbohydrate metabolic process (NUP214) transmembrane transport (NUP214)

Anatomy Link Frequency spinal 1 optic 1 NUP214 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuritis 6 99.16 Nerve growth factor 6 95.76 Potency 1 89.28 dorsal root ganglion 2 88.60 agonist 3 87.44 Spinal cord 1 87.24 antagonist 3 86.40 noradrenaline 2 80.32 intrathecal 1 79.68 Multiple sclerosis 3 73.72

Disease Link Frequency Relevance Heat Optic Neuritis 6 99.40 Congenital Anomalies 1 97.36 Nociception 4 94.40 Ganglion Cysts 2 88.60 Demyelinating Disease 3 73.72 Hyperalgesia 1 62.56 INFLAMMATION 1 61.72 Disease 1 57.72 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Can CSF predict the course of optic neuritis?

Gene_expression (predict) of Can in optic associated with optic neuritis and neuritis

1) Confidence 0.65 Published 1998 Journal Mult. Scler. Section Title Doc Link 9762661 Disease Relevance 0.74 Pain Relevance 0.55

Within cultured spinal cells, BDNF also activated CaN-dependent, NFAT-regulated gene expression.

Gene_expression (expression) of CaN in spinal

2) Confidence 0.65 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17488277 Disease Relevance 0.61 Pain Relevance 0.52

Although activation of alpha(2C)-AR is not linked to calcium mobilization, co-expression of these receptors with the chimeric Galpha(qi5) protein, containing the five carboxyl-terminal amino acids from G(i), or promiscuosus Galpha(16) protein can divert receptor signaling to the G(q) pathway generating Ca(2+) release from intracellular stores.

Gene_expression (co-expression) of can

3) Confidence 0.58 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19426776 Disease Relevance 0 Pain Relevance 0.17

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