INT77809

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NUP214) nucleoplasm (NUP214) small molecule metabolic process (NUP214)
nucleus (NUP214) carbohydrate metabolic process (NUP214) transmembrane transport (NUP214)
Anatomy Link Frequency
spinal 1
optic 1
NUP214 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 6 99.16 Very High Very High Very High
Nerve growth factor 6 95.76 Very High Very High Very High
Potency 1 89.28 High High
dorsal root ganglion 2 88.60 High High
agonist 3 87.44 High High
Spinal cord 1 87.24 High High
antagonist 3 86.40 High High
noradrenaline 2 80.32 Quite High
intrathecal 1 79.68 Quite High
Multiple sclerosis 3 73.72 Quite High
Disease Link Frequency Relevance Heat
Optic Neuritis 6 99.40 Very High Very High Very High
Congenital Anomalies 1 97.36 Very High Very High Very High
Nociception 4 94.40 High High
Ganglion Cysts 2 88.60 High High
Demyelinating Disease 3 73.72 Quite High
Hyperalgesia 1 62.56 Quite High
INFLAMMATION 1 61.72 Quite High
Disease 1 57.72 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Can CSF predict the course of optic neuritis?
Gene_expression (predict) of Can in optic associated with optic neuritis and neuritis
1) Confidence 0.65 Published 1998 Journal Mult. Scler. Section Title Doc Link 9762661 Disease Relevance 0.74 Pain Relevance 0.55
Within cultured spinal cells, BDNF also activated CaN-dependent, NFAT-regulated gene expression.
Gene_expression (expression) of CaN in spinal
2) Confidence 0.65 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17488277 Disease Relevance 0.61 Pain Relevance 0.52
Although activation of alpha(2C)-AR is not linked to calcium mobilization, co-expression of these receptors with the chimeric Galpha(qi5) protein, containing the five carboxyl-terminal amino acids from G(i), or promiscuosus Galpha(16) protein can divert receptor signaling to the G(q) pathway generating Ca(2+) release from intracellular stores.
Gene_expression (co-expression) of can
3) Confidence 0.58 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19426776 Disease Relevance 0 Pain Relevance 0.17

General Comments

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