INT7781

Context Info Confidence 0.60 First Reported 1983 Last Reported 1994 Negated 0 Speculated 0 Reported most in Title Documents 3 Total Number 3 Disease Relevance 0.26 Pain Relevance 1.90

lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1) plasma membrane (Ap2m1)

Anatomy Link Frequency heart 1 Ap2m1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 8 100.00 opioid receptor 5 100.00 Opioid 5 99.78 agonist 3 98.84 Dopamine 1 97.04 Delta opioid receptors 2 96.08 Morphine 2 95.00 Intracerebroventricular 1 92.36 tail-flick 1 91.00 Analgesic 1 90.20

Disease Link Frequency Relevance Heat Heart Rate Under Development 1 96.96 Bradycardia 2 96.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Evidence for differential opioid mu 1- and mu 2-receptor-mediated regulation of heart rate in the conscious rat.

Regulation (regulation) of mu 2 in heart associated with narcan and opioid

1) Confidence 0.60 Published 1992 Journal Neuropharmacology Section Title Doc Link 1356253 Disease Relevance 0.26 Pain Relevance 0.51

These data support our previous studies which have suggested mu 2 and delta opioid receptor regulation of the rat nigrostriatal pathway.

Regulation (regulation) of mu 2 associated with opioid receptor

2) Confidence 0.44 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6310456 Disease Relevance 0 Pain Relevance 0.63

Effect of selective mu 1, mu 2 and delta 2 opioid receptor agonists on gastric functions in the rat.

Regulation (Effect) of mu 2 associated with narcan, agonist and opioid receptor

3) Confidence 0.30 Published 1994 Journal Neuropharmacology Section Title Doc Link 7845553 Disease Relevance 0 Pain Relevance 0.77

General Comments

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