INT77823

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.56
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
hypothalamus 4
striatum 4
hippocampus 4
Notch 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 2 100.00 Very High Very High Very High
Hippocampus 12 99.84 Very High Very High Very High
Substantia nigra 57 99.68 Very High Very High Very High
Locus ceruleus 8 99.16 Very High Very High Very High
fluoxetine 6 98.64 Very High Very High Very High
Nucleus accumbens 1 97.16 Very High Very High Very High
Inflammation 46 96.92 Very High Very High Very High
antagonist 8 91.68 High High
Opioid 3 91.24 High High
Dopamine 55 90.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 52 96.92 Very High Very High Very High
Depression 2 79.12 Quite High
Drug Induced Neurotoxicity 7 77.52 Quite High
Disease 137 75.20 Quite High
Parkinson's Disease 19 75.00 Quite High
Death 16 70.88 Quite High
Cv Unclassified Under Development 1 70.36 Quite High
Neurodegenerative Disease 23 61.92 Quite High
Nerve Degeneration 2 49.48 Quite Low
Demyelinating Disease 4 18.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction in TH mRNA was blocked by cycloheximide consistent with a protein-dependent mechanism.
Negative_regulation (blocked) of Negative_regulation (reduction) of TH mRNA
1) Confidence 0.59 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.18
Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.
Negative_regulation (decreased) of Negative_regulation (levels) of TH in hypothalamus associated with locus ceruleus and fluoxetine
2) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.42
Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.
Negative_regulation (decreased) of Negative_regulation (levels) of tyrosine hydroxylase in hypothalamus associated with locus ceruleus and fluoxetine
3) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.42
The basal firing rate was not modified by either a single dose or repeated doses of MDMA, although the latter produced a shift to the right in the dose-response curve for clonidine-induced inhibition of the firing rate (ED(50) increased by 59%) and a reduction in tyrosine hydroxylase activity (20%) in the hippocampus.
Negative_regulation (inhibition) of Negative_regulation (reduction) of tyrosine hydroxylase in hippocampus associated with hippocampus and clonidine
4) Confidence 0.42 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12536039 Disease Relevance 0 Pain Relevance 0.35
The inhibitory effect of clonidine on tyrosine hydroxylase activity was markedly reduced in hippocampus of rats treated with DSP4 (10+/-5% vs 57+/-3% in the control group, P<0.001) but was not changed in parietal cortex and hypothalamus.
Negative_regulation (reduced) of Negative_regulation (effect) of tyrosine hydroxylase in hippocampus associated with hippocampus and clonidine
5) Confidence 0.34 Published 2001 Journal Pharmacol. Toxicol. Section Abstract Doc Link 11245411 Disease Relevance 0 Pain Relevance 0.60
The most important findings in the present study include the complete prevention of the loss of TH in the 6-OHDA-lesioned striatum and the decreased number of ubiquitin-positive intracellular inclusions.
Negative_regulation (prevention) of Negative_regulation (loss) of TH in striatum
6) Confidence 0.26 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.24 Pain Relevance 0.08
The data show that in the 6-OHDA-lesioned striatum, mildronate completely prevented the loss of TH, stimulated Notch-3 expression and decreased the expression of ubiquitin, GFAP and iNOS.
Negative_regulation (prevented) of Negative_regulation (loss) of TH in Notch
7) Confidence 0.26 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC3000094 Disease Relevance 0.45 Pain Relevance 0.05
CSC pretreatment partially attenuated the decrease in nigral tyrosine hydroxylase immunoreactivity induced by 6-OHDA, whereas no modification of the increase in preproenkephalin mRNA expression in the dorsolateral striatum was observed.
Negative_regulation (attenuated) of Negative_regulation (decrease) of tyrosine hydroxylase in striatum
8) Confidence 0.22 Published 2005 Journal Exp Brain Res Section Abstract Doc Link 15968457 Disease Relevance 0.26 Pain Relevance 0.47
g) produced the same degree of TH+ cell loss in the SN as a striatal injection of 22.5 ?
Negative_regulation (degree) of Negative_regulation (loss) of TH associated with substantia nigra
9) Confidence 0.12 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.31 Pain Relevance 0.49
The reduction of striatal dopaminergic content and tyrosine hydroxylase activity caused by METH, however, were not blocked by DADLE.
Negative_regulation (blocked) of Negative_regulation (reduction) of tyrosine hydroxylase
10) Confidence 0.03 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9765353 Disease Relevance 0.15 Pain Relevance 0.72

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