INT77848

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Context Info
Confidence 0.14
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (SSB) nucleus (SSB)
Anatomy Link Frequency
embryonic kidney 1
SSB (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 12 95.12 Very High Very High Very High
cocaine 6 92.44 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We expressed wild-type and mutant rat skeletal muscle (mu1) Na+ channels in human embryonic kidney cells to investigate the state-dependent modulation of LA receptor affinity.
Regulation (modulation) of LA receptor in embryonic kidney
1) Confidence 0.14 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9765517 Disease Relevance 0 Pain Relevance 0.37
Our data suggest that transitions in channel state indeed invoke conformational changes in the LA receptor and that lysine mutations in the LA receptor region alter such conformational changes during the transition to the inactivated state.
Regulation (changes) of LA receptor
2) Confidence 0.10 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9765517 Disease Relevance 0 Pain Relevance 0.16
Hille's modulated receptor hypothesis attributed the changes in LA affinity to state-dependent alterations in the conformation of the LA receptor.
Regulation (alterations) of LA receptor
3) Confidence 0.06 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9765517 Disease Relevance 0 Pain Relevance 0.39

General Comments

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