INT77855

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 55
Total Number 57
Disease Relevance 67.42
Pain Relevance 54.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
knee 8
nociceptors 3
T cells 3
nerve 2
B cells 2
Pain1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2481 100.00 Very High Very High Very High
Neuropathic pain 372 100.00 Very High Very High Very High
IPN 101 100.00 Very High Very High Very High
depression 73 100.00 Very High Very High Very High
Fibrositis 60 100.00 Very High Very High Very High
Chronic low back pain 45 100.00 Very High Very High Very High
Cancer pain 2 100.00 Very High Very High Very High
Anterior cingulate cortex 61 99.98 Very High Very High Very High
Serotonin 18 99.92 Very High Very High Very High
Inflammation 254 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2923 100.00 Very High Very High Very High
Neuropathic Pain 520 100.00 Very High Very High Very High
Inflammatory Pain 101 100.00 Very High Very High Very High
Depression 88 100.00 Very High Very High Very High
Low Back Pain 87 100.00 Very High Very High Very High
Neuromyelitis Optica 57 100.00 Very High Very High Very High
Fibromyalgia 48 100.00 Very High Very High Very High
Syndrome 47 100.00 Very High Very High Very High
Cancer Pain 2 100.00 Very High Very High Very High
INFLAMMATION 254 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of anti-DNA autoantibodies).
Gene_expression (Production) of auto
1) Confidence 0.75 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.14 Pain Relevance 0
Teodorescu [5] performed a longitudinal clinical study in a group of lupus patients and concluded that levels of anti-ss-DNA autoantibodies are the best predictors of a forthcoming increase in dsDNA levels and the SLE symptom flare.
Gene_expression (levels) of auto associated with systemic lupus erythematosus
2) Confidence 0.65 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.72 Pain Relevance 0
The detection of NMO specific serum auto-antibodies, collectively known as NMO-IgG, helps to allows early diagnostic distinction between NMO and MS [54, 56].
Gene_expression (detection) of auto associated with neuromyelitis optica and multiple sclerosis
3) Confidence 0.65 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 2.26 Pain Relevance 0.39
The drug has repeatedly been shown to be an antagonist at NMDAr, and our data suggested that its effects on spontaneous glutamate release were likely to be due to blockade of presynaptic facilitatory NMDA autoreceptors (see Berretta and Jones, 1996; Woodhall et al., 2001).
Gene_expression (presynaptic) of auto associated with glutamate and antagonist
4) Confidence 0.65 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0.41 Pain Relevance 0.22
Previously, we have shown that felbamate can decrease sEPSC frequency by blocking presynaptic facilitatory NMDA autoreceptors (Yang et al., 2007).
Gene_expression (presynaptic) of auto
5) Confidence 0.65 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.33
More than half of patients with diabetes due to a heterozygous INS mutation have been screened for the presence of beta-cell auto-antibodies (anti-GAD65, islet cell antibodies (ICA) and insulin antibodies).
Gene_expression (antibodies) of auto associated with diabetes mellitus
6) Confidence 0.65 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.60 Pain Relevance 0
E2f2 is the best candidate in this region considering that mice deficient for both E2F1 and E2F2 develop nonautoimmune, insulin-dependent diabetes with high penetrance [57].
Gene_expression (develop) of auto associated with diabetes mellitus
7) Confidence 0.65 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.74 Pain Relevance 0
After a few weeks, as the 5-HT1A and 5-HT1B autoreceptors become desensitized, serotonin is increased in the synapse region (Waldinger 2005).
Gene_expression (desensitized) of auto in synapse associated with serotonin
8) Confidence 0.65 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936309 Disease Relevance 0.24 Pain Relevance 0.55
AIDs represent a spectrum of diseases characterized by recurrent episodes of seemingly unprovoked inflammation that, unlike autoimmune disorders, lack the production of high-titer auto-antibodies or antigen-specific T cells [10].
Gene_expression (production) of auto in T cells associated with autoimmune disease, inflammation and disease
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.42 Pain Relevance 0.30
In contrast, most animals in which a pain killer was administered during surgery (62%), as well as those mice that received only anesthesia (70%) or anesthesia and analgesia (62%), had started burrowing by 7–9?
Gene_expression (killer) of pain associated with pain, anesthesia and analgesia
10) Confidence 0.53 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.25 Pain Relevance 0.48
In this way we could show that less than 30% of mice that had undergone surgery without pain alleviation had started burrowing 7–9?
Gene_expression (alleviation) of pain associated with pain
11) Confidence 0.53 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.25 Pain Relevance 0.45
The molecular genetic technique currently garnering the most interest is the use of transgenic mice that either overexpress, or do not express, presumably pain-related proteins.
Neg (not) Gene_expression (express) of pain-related associated with targeted disruption and pain
12) Confidence 0.51 Published 1998 Journal Pain Section Abstract Doc Link 9766829 Disease Relevance 0.84 Pain Relevance 0.58
Knee pain may also be part of a more widespread pain syndrome.
Gene_expression (syndrome) of pain in Knee associated with pain, syndrome and fibrositis
13) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.44 Pain Relevance 0.84
In a population study, long-standing knee pain in women was more often part of a widespread pain syndrome than knee pain in men (68% vs. 40%) [25].
Gene_expression (syndrome) of pain in knee associated with pain, syndrome and fibrositis
14) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.73 Pain Relevance 1.03
In future studies, and in the clinic, it may be of value to assess the subject's total body pain in order to separate subjects with knee pain only from those where knee pain is part of a widespread pain syndrome.
Gene_expression (syndrome) of pain in knee associated with pain, syndrome and fibrositis
15) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.84 Pain Relevance 1.14
In a population study, long-standing knee pain in women was more often part of a widespread pain syndrome than knee pain in men (68% vs. 40%) [25].
Gene_expression (syndrome) of pain in knee associated with pain, syndrome and fibrositis
16) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.73 Pain Relevance 1.03
Knee replacement is the most effective treatment in reducing pain due to osteoarthritis, and about 90% report satisfactory pain relief [26].
Gene_expression (reducing) of pain in Knee associated with pain and osteoarthritis
17) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.73 Pain Relevance 1.10
Knee pain may also be part of a more widespread pain syndrome.
Gene_expression (syndrome) of pain in Knee associated with pain, syndrome and fibrositis
18) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.45 Pain Relevance 0.84
In future studies, and in the clinic, it may be of value to assess the subject's total body pain in order to separate subjects with knee pain only from those where knee pain is part of a widespread pain syndrome.
Gene_expression (syndrome) of pain in knee associated with pain, syndrome and fibrositis
19) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.82 Pain Relevance 1.13
In a population study, long-standing knee pain in women was more often part of a widespread pain syndrome than knee pain in men (68% vs. 40%) [25].
Gene_expression (syndrome) of pain in knee associated with pain, syndrome and fibrositis
20) Confidence 0.46 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1471783 Disease Relevance 1.72 Pain Relevance 1.02

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