INT7786

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 5.62
Pain Relevance 14.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptgdr) signal transducer activity (Ptgdr)
Anatomy Link Frequency
striatum 3
nucleus accumbens 2
heart 2
spinal cord 1
neurons 1
Ptgdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 370 100.00 Very High Very High Very High
antagonist 108 99.96 Very High Very High Very High
Somatostatin 5 99.84 Very High Very High Very High
Nucleus accumbens 68 99.68 Very High Very High Very High
Pain 19 99.68 Very High Very High Very High
analgesia 8 99.44 Very High Very High Very High
Neuropeptide 11 99.34 Very High Very High Very High
substance P 14 99.04 Very High Very High Very High
Spinal cord 5 99.04 Very High Very High Very High
agonist 223 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Eating Disorder 18 99.82 Very High Very High Very High
Pain 24 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 2 99.68 Very High Very High Very High
Neuropathic Pain 2 98.96 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.32 Very High Very High Very High
Erectile Dysfunction 8 98.24 Very High Very High Very High
Coronary Artery Disease 1 95.08 Very High Very High Very High
Neuroblastoma 4 94.52 High High
Nociception 14 93.48 High High
Hypothermia 4 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in basal D2 receptor density in the mesencephalon of handled rats, which was suppressed after morphine CPP, was observed.
Positive_regulation (increase) of D2 receptor in mesencephalon
1) Confidence 0.47 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17492273 Disease Relevance 0.06 Pain Relevance 0
Also, the heart rate lowering effect via stimulation of the D2-receptor by lisuride was more marked with increased concentration of norepinephrine in the synaptic cleft.
Positive_regulation (stimulation) of D2-receptor in heart
2) Confidence 0.47 Published 1994 Journal Yonsei Med. J. Section Abstract Doc Link 7871845 Disease Relevance 0.14 Pain Relevance 0.07
Antagonist studies further supported a food restriction-induced enhancement of the D2 receptor activity because the D2 antagonist 3-[4-(4-chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole (L741,626) recovered pramipexole-induced yawning to free-fed levels, whereas yawning and PE were suppressed following pretreatment with the D3 antagonist N-{4-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-pyridine-2-yl-benzamide hydrochloride (PG01037).
Positive_regulation (enhancement) of D2 receptor associated with erectile dysfunction, antagonist and eating disorder
3) Confidence 0.42 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305018 Disease Relevance 0.92 Pain Relevance 0.48
Food restriction resulted in a suppression of pramipexole-induced yawning, a sensitized hypothermic response, and an enhanced locomotor response to pramipexole, effects that are suggestive of an enhanced D2 receptor activity; no effect on pramipexole-induced PE was observed.
Positive_regulation (enhanced) of D2 receptor associated with erectile dysfunction and eating disorder
4) Confidence 0.42 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305018 Disease Relevance 0.99 Pain Relevance 0.56
The results suggest that D2 receptor is involved in pain modulation and activation of D2 receptor and enhances AA in the spinal cord, while such effect is absent in D1 receptor and inactivation of D1 receptor attenuates AA.
Positive_regulation (activation) of D2 receptor in spinal cord associated with pain, spinal cord and analgesia
5) Confidence 0.41 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324516 Disease Relevance 0.35 Pain Relevance 1.72
D2 receptor activation appears to play an important role in the desensitization of delta receptors, because concurrent administration of the D2 antagonist eticlopride with morphine prevented the densitization of delta and D2 receptors.
Positive_regulation (activation) of D2 receptor associated with antagonist and morphine
6) Confidence 0.41 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 1.00
On the other hand, talipexole might weaken 5-HT release from EC cells elicited by D2 receptor stimulation with its 5-HT3 receptor blocking property.
Positive_regulation (stimulation) of D2 receptor
7) Confidence 0.37 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10604273 Disease Relevance 0.13 Pain Relevance 0.59
These results demonstrate that the hypotension resulting from DP receptor activation in the rat is mediated primarily through vasodilation of arterioles of skeletal muscle independent of changes in blood flow to vital organs.
Positive_regulation (activation) of DP receptor in arterioles associated with pressure volume 2 under development and increased venous pressure under development
8) Confidence 0.32 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16405449 Disease Relevance 0.25 Pain Relevance 0.07
This treatment did not induce any change in D1 receptor, preproenkephalin A or substance P messenger RNA content in the striatum, whereas D2 receptor messenger RNA was increased in the striatum of treated rats.
Positive_regulation (increased) of D2 receptor in striatum associated with substance p
9) Confidence 0.30 Published 1995 Journal Neuroscience Section Abstract Doc Link 7539897 Disease Relevance 0.13 Pain Relevance 0.40
The present data reveal that neuronal activity in the NAC is necessary for behaviorally induced increases in cortical ACh efflux and that this activation does not require increases in D2 receptor activity.
Neg (not) Positive_regulation (increases) of D2 receptor in NAC associated with nucleus accumbens
10) Confidence 0.28 Published 2004 Journal Neuroscience Section Abstract Doc Link 14706776 Disease Relevance 0 Pain Relevance 0.51
Dopaminergic modulation of striatal neuropeptides: differential effects of D1 and D2 receptor stimulation on somatostatin, neuropeptide Y, neurotensin, dynorphin and enkephalin.
Positive_regulation (stimulation) of D2 receptor associated with dynorphin, somatostatin, neuropeptide and enkephalin
11) Confidence 0.24 Published 1992 Journal Brain Res. Section Title Doc Link 1356580 Disease Relevance 0 Pain Relevance 0.86
Microscopic analysis revealed that it was the number of medium-sized neurons expressing D2 receptor messenger RNA that was significantly enhanced, while the mean amount of message per cell remained unchanged.
Positive_regulation (enhanced) of D2 receptor in neurons
12) Confidence 0.22 Published 1995 Journal Neuroscience Section Abstract Doc Link 7539897 Disease Relevance 0.12 Pain Relevance 0.39
Moreover, these EC50 values were also obtained studying DA- and amphetamine-induced D2 receptor activation, resulting in inhibition of the electrically evoked release of [14C]acetylcholine from the slices.
Positive_regulation (amphetamine-induced) of D2 receptor associated with dopamine
13) Confidence 0.21 Published 1994 Journal Synapse Section Abstract Doc Link 7974202 Disease Relevance 0 Pain Relevance 0.48
Rats with persistent VCMs (+VCM) had increased D2 receptor, ENK, and DYN mRNA in both striatal regions, and increased ENK and DYN mRNA in the nucleus accumbens, compared with controls.
Positive_regulation (increased) of D2 receptor in nucleus accumbens associated with nucleus accumbens
14) Confidence 0.21 Published 1994 Journal Synapse Section Abstract Doc Link 7531873 Disease Relevance 0.21 Pain Relevance 0.39
Together, these data suggest that changes in D2 receptor activation directly in the striatum are responsible for the effects of quinpirole on enkephalin messenger RNA.
Positive_regulation (activation) of D2 receptor in striatum associated with enkephalin
15) Confidence 0.20 Published 1994 Journal Neuroscience Section Abstract Doc Link 7534387 Disease Relevance 0 Pain Relevance 0.71
For instance, since the inhibitory effect of opioid and muscarinic receptor activation on adenylate cyclase activity has been shown to be inversely related to the degree of DA D2 receptor activation, the degree of activation of D1 and D2 receptors by released DA is suggested to act as a functional gate allowing distinct neurotransmitters to play a role in striatal neurotransmission.
Positive_regulation (activation) of D2 receptor associated with neurotransmitter, dopamine and opioid
16) Confidence 0.19 Published 1994 Journal Synapse Section Abstract Doc Link 7974202 Disease Relevance 0 Pain Relevance 0.56
Rats that did not develop VCMs (-VCM) had increased D2 receptor and DYN mRNA, and reduced substance P mRNA in the dorsolateral striatum.
Positive_regulation (increased) of D2 receptor in striatum associated with substance p
17) Confidence 0.15 Published 1994 Journal Synapse Section Abstract Doc Link 7531873 Disease Relevance 0.21 Pain Relevance 0.39
Functionally, activation of the vascular DA receptor (D1 receptor) causes smooth muscle relaxation, whereas activation of the neuronal DA receptor (D2 receptor) reduces the response of the heart to nerve stimulation by depressing noradrenaline release [22, 27, 45, 48].
Positive_regulation (activation) of D2 receptor in heart associated with dopamine and noradrenaline
18) Confidence 0.15 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.37 Pain Relevance 0.78
Induction of dopamine (DA) D2 receptor supersensitivity by the agonist quinpirole was discovered approximately 15 years ago, and was found to occur consistently if rats were treated repeatedly at daily or weekly or monthly intervals with low or high doses of quinpirole.
Positive_regulation (Induction) of D2 receptor associated with dopamine and agonist
19) Confidence 0.13 Published 2004 Journal Neurotox Res Section Abstract Doc Link 15639779 Disease Relevance 0 Pain Relevance 0.44
Dopamine decreases striatal enkephalin turnover and proenkephalin messenger RNA abundance via D2 receptor activation in primary striatal cell cultures.
Positive_regulation (activation) of D2 receptor associated with dopamine and enkephalin
20) Confidence 0.13 Published 1993 Journal Neuroscience Section Title Doc Link 8487949 Disease Relevance 0 Pain Relevance 0.94

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