INT7787

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Context Info
Confidence 0.66
First Reported 1981
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 52
Total Number 55
Disease Relevance 3.55
Pain Relevance 31.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1) oxidoreductase activity (Akr1d1) cytoplasm (Akr1d1)
Anatomy Link Frequency
neurons 7
striatum 4
brain 2
PFC 2
ventral 2
Akr1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1094 100.00 Very High Very High Very High
agonist 161 100.00 Very High Very High Very High
dopamine receptor 51 100.00 Very High Very High Very High
Serotonin 29 100.00 Very High Very High Very High
addiction 10 99.96 Very High Very High Very High
Opioid 15 99.90 Very High Very High Very High
Somatostatin 5 99.84 Very High Very High Very High
Spinal cord 5 99.80 Very High Very High Very High
Neuropeptide 9 99.48 Very High Very High Very High
Morphine 14 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Catalepsy 7 99.48 Very High Very High Very High
Neuropathic Pain 2 99.24 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 99.00 Very High Very High Very High
Depression 18 98.64 Very High Very High Very High
Nociception 23 96.92 Very High Very High Very High
Pain 20 90.40 High High
Muscle Rigidity 1 84.24 Quite High
Generalized Anxiety Disorder 3 77.84 Quite High
Stress 9 75.00 Quite High
Vomiting 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results are consistent with the interpretation that pergolide produces an antinociceptive action at the spinal cord level by stimulating both D1 and D2 dopamine receptors.
Positive_regulation (stimulating) of D1 in spinal cord associated with dopamine receptor, antinociceptive and spinal cord
1) Confidence 0.66 Published 1991 Journal Life Sci. Section Abstract Doc Link 2046457 Disease Relevance 0.07 Pain Relevance 0.32
Furthermore, the ability of dexamphetamine, primarily an indirect dopamine agonist, to excite striatal neurons in these anaesthetized animals suggests that stimulation of both D1 and D2 receptors is not abolished by anaesthesia.
Positive_regulation (stimulation) of D1 in neurons associated with dopamine and agonist
2) Confidence 0.66 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3244408 Disease Relevance 0 Pain Relevance 0.25
This finding strongly suggests that the sensitivity of striatal DA, D1 and D2, receptors to apomorphine was increased by methyl bromide exposure.
Positive_regulation (increased) of D1 associated with dopamine
3) Confidence 0.38 Published 1994 Journal Ind Health Section Abstract Doc Link 7928421 Disease Relevance 0.07 Pain Relevance 0.52
Interestingly, SCH 23390, a selective blocker of D1 dopamine (DA) receptors which, given chronically to rats, induces a 32% increase in D1 receptor number and increases the Vmax of D1-stimulated striatal AC, resulted in marked resistance to acute morphine effects.
Positive_regulation (increase) of D1 associated with dopamine and morphine
4) Confidence 0.23 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2531233 Disease Relevance 0.08 Pain Relevance 0.64
For instance, since the inhibitory effect of opioid and muscarinic receptor activation on adenylate cyclase activity has been shown to be inversely related to the degree of DA D2 receptor activation, the degree of activation of D1 and D2 receptors by released DA is suggested to act as a functional gate allowing distinct neurotransmitters to play a role in striatal neurotransmission.
Positive_regulation (activation) of D1 associated with neurotransmitter, dopamine and opioid
5) Confidence 0.15 Published 1994 Journal Synapse Section Abstract Doc Link 7974202 Disease Relevance 0 Pain Relevance 0.56
These results indicate that the release of serotonin in the median raphe nucleus does not appear to be regulated by dopaminergic afferents through the activation of dopamine D1 or D2 receptors.
Positive_regulation (activation) of D1 in raphe nucleus associated with dopamine, raphe and serotonin
6) Confidence 0.12 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383619 Disease Relevance 0 Pain Relevance 0.90
Activation of dopamine D1-like receptors excites LTS interneurons of the striatum.
Positive_regulation (Activation) of D1 in interneurons associated with dopamine
7) Confidence 0.09 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12099911 Disease Relevance 0 Pain Relevance 0.66
In conclusion, our results suggest that (i) dopamine agonists can exert an excitatory influence on depolarization-induced GABA release within neostriatum via D1 receptors and an inhibitory influence via D2 receptors; (ii) under the conditions of these experiments, endogenous dopamine fails to act on D1 sites but does exert an inhibitory influence via D2 sites; and (iii) there is an interaction between D1 and D2 receptors such that the actions of dopamine mediated via D1 sites are inhibited as a result of the concomitant actions exerted via D2 sites.
Positive_regulation (mediated) of D1 associated with gaba, dopamine and agonist
8) Confidence 0.07 Published 1997 Journal Neuroscience Section Abstract Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.57
These latter results suggest that there is an interaction between D1 and D2 receptors whereby the effects of dopamine mediated via D1 sites are inhibited by an action on D2 sites.
Positive_regulation (mediated) of D1 associated with dopamine
9) Confidence 0.07 Published 1997 Journal Neuroscience Section Abstract Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.89
However, both effects required coactivation of D1- and D2-like receptors.
Spec (like) Positive_regulation (coactivation) of D1
10) Confidence 0.06 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11158242 Disease Relevance 0 Pain Relevance 0.65
It was tested whether the antagonist effects were due to dopamine receptor blockade or increased tone on D1/D2 receptors.
Spec (whether) Positive_regulation (increased) of D1 associated with dopamine receptor and antagonist
11) Confidence 0.05 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12390525 Disease Relevance 0 Pain Relevance 0.88
Thus, pre-activation of D1 receptors in the accumbens was essential for the subsequent physiological expression of D2 receptors in inducing an increase in the firing rate of VP neurones.
Positive_regulation (activation) of D1
12) Confidence 0.05 Published 1989 Journal Brain Res. Section Abstract Doc Link 2568154 Disease Relevance 0 Pain Relevance 0.88
These data indicate that the synergistic response to combined D1- and D2-receptor stimulation is mediated by interneuronal interactions involving the activation of D1 and D2 receptors on separate populations of striatal neurons.
Positive_regulation (activation) of D1 in neurons
13) Confidence 0.04 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 8613751 Disease Relevance 0 Pain Relevance 0.79
Bromocriptine might induce 5-HT release by stimulating D1, D2 and 5-HT3 receptors and depolarizing neurons in the ileum.
Positive_regulation (stimulating) of D1 in neurons
14) Confidence 0.04 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10604273 Disease Relevance 0.13 Pain Relevance 0.61
D1 dopamine receptor-mediated activation of adenylate cyclase by SKF38393 was inhibited by morphine in an additive fashion, but the opiate had minimal effects on the net activation of adenylate cyclase by dopamine which activates both D1 and D2 receptors.
Positive_regulation (activates) of D1 associated with dopamine, dopamine receptor, opiate and morphine
15) Confidence 0.04 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3015643 Disease Relevance 0 Pain Relevance 0.81
These data suggest that hyperactivity of the opioid and dopamine systems (specifically mediated through D1 receptors) is involved in such behaviour.
Positive_regulation (mediated) of D1 associated with dopamine, attention deficit hyperactivity disorder and opioid
16) Confidence 0.03 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2892686 Disease Relevance 0.32 Pain Relevance 0.61
These results suggest that the increases, but not decreases, in ventral hippocampal activity have a measurable effect on ongoing rates of locomotion, and that this effect requires both D1 and D2 receptors.
Positive_regulation (requires) of D1 in ventral
17) Confidence 0.03 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613497 Disease Relevance 0 Pain Relevance 0.79
In contrast, none of the treatments increased D1 mRNA in any of the regions examined.
Positive_regulation (increased) of D1
18) Confidence 0.03 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9888623 Disease Relevance 0 Pain Relevance 1.05
D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons.
Positive_regulation (coactivation) of D1 in neurons associated with dopamine receptor
19) Confidence 0.03 Published 1995 Journal J. Neurosci. Section Title Doc Link 8613751 Disease Relevance 0 Pain Relevance 0.40
The above data suggests D1/D2 interdependence in catalepsy and a modulatory role of D1 and D2 DA receptor stimulation on the anticataleptic effect of MK-801.
Positive_regulation (stimulation) of D1 associated with dopamine and catalepsy
20) Confidence 0.03 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1365866 Disease Relevance 0.40 Pain Relevance 0.24

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