INT77874

Context Info Confidence 0.01 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.12

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)

Uvbi1 (Mus musculus) POMC (Homo sapiens)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 1 88.84 cytokine 2 53.92

Disease Link Frequency Relevance Heat Necrosis 2 96.20 Cancer 2 95.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MSH receptor (MSH-R) binding activity was upregulated by UVB, IL-1alpha, -1beta and ET-1, but was downregulated by TNF-alpha.

UVB Positive_regulation (upregulated) of MSH receptor

1) Confidence 0.01 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9767234 Disease Relevance 0.34 Pain Relevance 0.12

General Comments

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