INT77877

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Context Info
Confidence 0.38
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 3.31
Pain Relevance 10.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
photoreceptors 1
pons 1
medulla 1
spinal cord 1
brain 1
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 39 100.00 Very High Very High Very High
agonist 21 100.00 Very High Very High Very High
narcan 14 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
antinociception 9 100.00 Very High Very High Very High
Cannabinoid receptor 7 100.00 Very High Very High Very High
MU agonist 7 100.00 Very High Very High Very High
Kappa opioid receptor 5 100.00 Very High Very High Very High
Glutamate receptor 5 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 100.00 Very High Very High Very High
Diabetes Mellitus 30 99.80 Very High Very High Very High
Pain 3 97.88 Very High Very High Very High
Bordatella Infection 1 97.84 Very High Very High Very High
Hyperglycemia 4 93.12 High High
Injury 8 90.88 High High
Urological Neuroanatomy 7 90.56 High High
Targeted Disruption 5 75.00 Quite High
Night Blindness 44 52.48 Quite High
Depression 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in G-protein activity mediated through the stimulation of dopamine and GABA(B) receptors in the mesolimbic dopaminergic system of morphine-sensitized mice.
Regulation (Changes) of G-protein associated with gaba, dopamine and morphine
1) Confidence 0.38 Published 2003 Journal Addict Biol Section Title Doc Link 13129834 Disease Relevance 0 Pain Relevance 0.83
The present study was designed to investigate in streptozotocin-induced diabetic mice the effect of the selective micro-opioid agonist [D-Ala(2), NMePhe(4), Gly-ol(5)]enkephalin (DAMGO) on G-protein activation by monitoring guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to pons/medulla membranes, which contain the key areas for opioid antinociception.
Regulation (effect) of G-protein in medulla associated with antinociception, medulla, mu agonist, diabetes mellitus, enkephalin and opioid
2) Confidence 0.19 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.99 Pain Relevance 0.93
The effects of repeated s.c. administrations of an mu-opioid receptor antagonist naloxone on the G-protein activation induced by mu-opioid receptor agonists [D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO), endomorphin-1 and endomorphin-2 in the mouse spinal cord was studied, monitoring guanosine-5'-o-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding.
Regulation (effects) of G-protein in spinal cord associated with antagonist, agonist, narcan, enkephalin, opioid receptor and spinal cord
3) Confidence 0.11 Published 2001 Journal Brain Res. Section Abstract Doc Link 11549382 Disease Relevance 0 Pain Relevance 0.64
The aim of the present study was to investigate whether repeated treatment with the mu-opioid receptor antagonist naloxone could affect G-protein activation induced by a selective mu-opioid receptor agonist [D-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) in mice lacking the protein kinase Cgamma isoform monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
Regulation (affect) of G-protein associated with antagonist, agonist, narcan, enkephalin and opioid receptor
4) Confidence 0.11 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12566163 Disease Relevance 0.07 Pain Relevance 0.54
The present study was designed to investigate in streptozotocin-induced diabetic mice the effect of the selective micro-opioid agonist [D-Ala(2), NMePhe(4), Gly-ol(5)]enkephalin (DAMGO) on G-protein activation by monitoring guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to pons/medulla membranes, which contain the key areas for opioid antinociception.
Regulation (effect) of G-protein in pons associated with antinociception, medulla, mu agonist, diabetes mellitus, enkephalin and opioid
5) Confidence 0.06 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.99 Pain Relevance 0.93
On the contrary, either repeated administration of morphine (s.c. or i.c.v.) or SNC-80 failed to affect the kappa-opioid receptor agonist-induced antinociception and G-protein activation.
Neg (failed) Regulation (affect) of G-protein associated with antinociception, agonist, kappa opioid receptor and morphine
6) Confidence 0.06 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975677 Disease Relevance 0 Pain Relevance 1.24
Therefore, the affinity exhibited by opioid agonists of mu-ORs, but not antagonists, depends on the nature of the G-protein coupled to these receptors.
Regulation (depends) of G-protein associated with mu agonist and antagonist
7) Confidence 0.04 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767386 Disease Relevance 0 Pain Relevance 0.89
Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling.
Neg (not) Regulation (dependent) of G-protein associated with tolerance and opioid receptor
8) Confidence 0.03 Published 2002 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11900797 Disease Relevance 0.10 Pain Relevance 1.14
To that end, we studied the influence of NE on mu-opioid receptor (MOR) mRNA expression and MOR mediated G-protein signaling.
Regulation (influence) of G-protein associated with opioid receptor
9) Confidence 0.03 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.14 Pain Relevance 1.05
In the CNS, several regulators of G-protein signalling (RGS) modulate the activity of mu-opioid receptors.
Regulation (regulators) of G-protein associated with mu opioid receptor
10) Confidence 0.03 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.32 Pain Relevance 0.51
In the CNS, the regulators of G-protein signaling (RGS) proteins belonging to the Rz subfamily, RGS19 (G(alpha) interacting protein (GAIP)) and RGS20 (Z1), control the activity of opioid agonists at mu but not at delta receptors.
Regulation (regulators) of G-protein associated with mu agonist
11) Confidence 0.02 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14997173 Disease Relevance 0 Pain Relevance 0.37
The present studies examined the effect of chronic neuropathic pain on cannabinoid receptor density and receptor-mediated G-protein activity within supraspinal brain areas involved in pain processing and modulation in mice.
Spec (examined) Regulation (effect) of G-protein in brain associated with pain, cannabinoid receptor and neuropathic pain
12) Confidence 0.02 Published 2010 Journal Brain Res. Section Abstract Doc Link 20380816 Disease Relevance 0.65 Pain Relevance 0.62
The release of glutamate from photoreceptors modulates the photoresponse of ON BCs [35] via metabotropic glutamate receptor 6 (mGluR6) and the G-protein (Go) that regulates a cation channel [36-38].
Regulation (modulates) of G-protein in photoreceptors associated with glutamate and glutamate receptor
13) Confidence 0.00 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.05 Pain Relevance 0.10
There are multiple regulators of G-protein signaling (RGS) (Chidiac and Roy 2003) that directly modulate G-protein function; multiple receptors for activated PKC (RACKs) that may be important for translocation of PKC to specific intracellular locations; and multiple anchoring proteins that can regulate the location, function, and interaction of various protein kinases (Scott 1997; Bayer and Schulman 2001).
Regulation (modulate) of G-protein associated with kinase c
14) Confidence 0.00 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0 Pain Relevance 0.24

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