INT77887

Context Info Confidence 0.50 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 3.90 Pain Relevance 0.54

Anatomy Link Frequency lymphocytes 1 TRAM 1 Spt (Mus musculus)

Pain Link Frequency Relevance Heat abdominal pain 5 99.70 hyperpathia 3 99.44 Hsan 2 90.48 Pain 1 34.88 Bile 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Cancer 74 100.00 Targeted Disruption 9 99.70 Abdominal Pain 5 99.70 Hyperalgesia 3 99.44 Hernia 4 97.46 Death 2 95.36 Diabetic Nephropathy 3 95.20 Apoptosis 2 95.08 Necrosis 2 94.52 Neuropathic Pain 3 91.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Simple loss of SPT activity also cannot account for the HSAN1 phenotype, since heterozygous SPTLC1 knock-out mice have reduced SPT activity but are otherwise normal.

Negative_regulation (loss) of SPT associated with targeted disruption

1) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19923297 Disease Relevance 0.53 Pain Relevance 0.09

Simple loss of SPT activity also cannot account for the HSAN1 phenotype, since heterozygous SPTLC1 knock-out mice have reduced SPT activity but are otherwise normal.

Negative_regulation (reduced) of SPT associated with targeted disruption

2) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19923297 Disease Relevance 0.52 Pain Relevance 0.08

We previously reported that mice bearing a transgene-expressing mutant SPTLC1 (tgSPTLC1(C133W)) show a reduction in SPT activity and hyperpathia at 10 months of age.

Negative_regulation (reduction) of SPT associated with hyperpathia

3) Confidence 0.44 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19923297 Disease Relevance 0.43 Pain Relevance 0.10

Considering the superiority of MRI in terms of correlation between radiological and clinicopathological findings in SPT, MRI was strongly proposed for the diagnosis of SPT.6,10,18 Consistently, in our study, the diagnosis of SPT suggested by MRI was ultimately confirmed pathologically.

Negative_regulation (diagnosis) of SPT associated with cancer

4) Confidence 0.30 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2934730 Disease Relevance 1.36 Pain Relevance 0

However, the decrease in SPT activity had no effect on de novo sphingolipid biosynthesis, cellular sphingolipid content, cell proliferation and death (apoptosis and necrosis).

Negative_regulation (decrease) of SPT associated with necrosis, apoptosis and death

5) Confidence 0.12 Published 2004 Journal Biochim. Biophys. Acta Section Abstract Doc Link 14990347 Disease Relevance 0.37 Pain Relevance 0.09

Here, we show a 44% reduction of SPT activity in transformed lymphocytes from HSN1 patients with mutation T399G in the SPTLC1 gene.

Negative_regulation (reduction) of SPT in lymphocytes

6) Confidence 0.12 Published 2004 Journal Biochim. Biophys. Acta Section Abstract Doc Link 14990347 Disease Relevance 0.33 Pain Relevance 0.09

This hernia rate was not influenced by the type of TRAM (SPT or DPT). 20% of patients complained of residual abdominal pain, and 36% of a decrease of their abdominal strength after SPT.

Negative_regulation (decrease) of SPT in TRAM associated with abdominal pain and hernia

7) Confidence 0.06 Published 1997 Journal Ann Chir Plast Esthet Section Abstract Doc Link 9768148 Disease Relevance 0.37 Pain Relevance 0.10

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