INT77925

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Context Info
Confidence 0.53
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 15.23
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
MKN-45 2
hepatocytes 1
liver 1
brain 1
telomere 1
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 14 99.98 Very High Very High Very High
Kinase C 142 99.76 Very High Very High Very High
cINOD 17 99.48 Very High Very High Very High
Bioavailability 2 96.72 Very High Very High Very High
positron emission tomography 8 93.96 High High
Inflammation 28 93.72 High High
backache 1 88.48 High High
peripheral neuropathy 4 77.68 Quite High
headache 8 75.32 Quite High
agonist 14 71.76 Quite High
Disease Link Frequency Relevance Heat
Aging 21 99.92 Very High Very High Very High
Pancreatic Cancer 19 99.82 Very High Very High Very High
Cancer 309 99.80 Very High Very High Very High
Stomach Cancer 15 99.48 Very High Very High Very High
Prostate Cancer 13 99.48 Very High Very High Very High
Necrosis 6 98.44 Very High Very High Very High
Apoptosis 67 98.08 Very High Very High Very High
Chromosomal Instability 9 98.02 Very High Very High Very High
Genomic Instability 4 98.00 Very High Very High Very High
Chronic Hepatitis 12 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of telomerase activity in patients with pancreatic cancer.
Negative_regulation (Detection) of telomerase associated with pancreatic cancer
1) Confidence 0.53 Published 2005 Journal Methods Mol. Med. Section Title Doc Link 15542908 Disease Relevance 0.76 Pain Relevance 0
We report a patient with pancreatic cancer in whom telomerase activity had been detected in the pancreatic juice 19 months before he was diagnosed as having pancreatic cancer.
Negative_regulation (detected) of telomerase associated with pancreatic cancer
2) Confidence 0.41 Published 1998 Journal Am. J. Gastroenterol. Section Abstract Doc Link 9772067 Disease Relevance 0.72 Pain Relevance 0.19
Therefore, inhibition of telomerase activation and/or accelerated telomere shortening in patients with chronic hepatitis may limit hepatocyte proliferation and survival with impairment of regenerative capability.
Negative_regulation (inhibition) of telomerase in telomere associated with chronic hepatitis
3) Confidence 0.37 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.63 Pain Relevance 0.05
Pigs display no or very low levels of telomerase activity in the liver [20].
Negative_regulation (levels) of telomerase in liver
4) Confidence 0.28 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.28 Pain Relevance 0
Most differentiated human cells, including quiescent hepatocytes, have low or undetectable levels of telomerase activity [12].
Negative_regulation (levels) of telomerase in hepatocytes
5) Confidence 0.28 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.39 Pain Relevance 0
Such studies should be conducted before telomerase inhibitors are utilized in clinical studies to treat cancer patients [41].


Negative_regulation (inhibitors) of telomerase associated with cancer
6) Confidence 0.28 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.67 Pain Relevance 0.07
Also, NSAIDs at 25 microM (sulindac sulfone) decreased growth and telomerase activity in MCG-101 cells, without any effects on PGE2 production, while ibuprofen reduced PGE2 production but had no effect on growth or telomerase activity.
Negative_regulation (decreased) of telomerase associated with cinod
7) Confidence 0.26 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11295037 Disease Relevance 1.10 Pain Relevance 0.18
Our results demonstrate that cyclooxygenase inhibitors can retard tumor growth both in murine tumors and in human tumor cells by inhibition of telomerase activity in addition to previously recognized mechanisms as induction of apoptosis, inhibition of cell proliferation, influence on the expression of growth factors around growing tumors and attenuation of neoangiogenesis.
Negative_regulation (inhibition) of telomerase associated with cancer and apoptosis
8) Confidence 0.26 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11295037 Disease Relevance 1.17 Pain Relevance 0.15
The inhibition of telomerase activity by NSAIDs (indomethacin, mobic, sulindac sulfone, suramin) was, however, not a universal finding, since a mouse melanoma (K1735-M2) did not respond.
Negative_regulation (inhibition) of telomerase associated with cinod and skin cancer
9) Confidence 0.26 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11295037 Disease Relevance 0.86 Pain Relevance 0.16
In the gastric cancer cell line MKN-45 nimesulide caused a time- and dose-dependent reduction in cell numbers and significantly inhibited telomerase and Akt/PKB activity; the inhibition of telomerase activity was partly associated with the attenuation of Akt/PKB activity.
Negative_regulation (inhibition) of telomerase in MKN-45 associated with stomach cancer
10) Confidence 0.20 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15309882 Disease Relevance 0.46 Pain Relevance 0.21
In the gastric cancer cell line MKN-45 nimesulide caused a time- and dose-dependent reduction in cell numbers and significantly inhibited telomerase and Akt/PKB activity; the inhibition of telomerase activity was partly associated with the attenuation of Akt/PKB activity.
Negative_regulation (inhibited) of telomerase in MKN-45 associated with stomach cancer
11) Confidence 0.20 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15309882 Disease Relevance 0.46 Pain Relevance 0.20
These results demonstrate that the selective COX-2 inhibitor suppresses the telomerase activity of gastric cancer cells, in part by blocking the activation of protein kinase B, which provides a new signaling mechanism responsible for the anticancer effects of the selective COX-2 inhibitor.
Negative_regulation (suppresses) of telomerase associated with cox-2 inhibitor and stomach cancer
12) Confidence 0.14 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15309882 Disease Relevance 0.39 Pain Relevance 0.16
In the present study, since Receptor Ck activation has been found to down-regulate hTERT transcription, it is expected to repress telomerase activity as well, because the enzymatic activity of telomerase can not possibly occur in the absence of hTERT, the catalytic subunit of telomerase.
Negative_regulation (repress) of telomerase
13) Confidence 0.06 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.26 Pain Relevance 0
Among the multiple components of human telomerase, only the catalytic subunit, hTERT seems to be the key determinant of telomerase activity.
Negative_regulation (determinant) of telomerase
14) Confidence 0.05 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.23 Pain Relevance 0
Kim et al. [33] observed that PKC inhibitors decreased telomerase activities by decreasing the expression of full length hTERT transcripts in human cervical cancers.
Negative_regulation (decreased) of telomerase associated with cervical cancer and kinase c
15) Confidence 0.05 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0.50
GRN163L is an oligonucleotide that binds to the RNA active site of telomerase, thereby inhibiting telomerase activity.
Negative_regulation (inhibiting) of telomerase
16) Confidence 0.04 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.56 Pain Relevance 0.36
GRN163L, a telomerase inhibitor
Negative_regulation (inhibitor) of telomerase
17) Confidence 0.04 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.62 Pain Relevance 0.39
When UV-exposed LEC were allowed to recover in the presence of either 5.0 or 10.0 µM AR-12, there was a significant (p<0.05) decrease in telomerase activity compared to the cells that were irradiated and received 0.0 µM AR-12 (Figure 2C).


Negative_regulation (decrease) of telomerase
18) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.11 Pain Relevance 0
Telomerase activity decreased in a dose-dependent manner.
Negative_regulation (decreased) of Telomerase
19) Confidence 0.02 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994344 Disease Relevance 0.61 Pain Relevance 0
Thus, this peculiar low level chromosome instability reflects an underlying defect in chromosome maintenance, though probably not due to a generalized defect in telomerase activity[15].
Negative_regulation (defect) of telomerase associated with chromosomal instability
20) Confidence 0.02 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954972 Disease Relevance 1.47 Pain Relevance 0

General Comments

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