INT77927

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
livers 2
hepatocytes 2
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 91.44 High High
agonist 5 87.96 High High
Antiemetics 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 98.04 Very High Very High Very High
Hepatotoxicity 3 88.24 High High
Congenital Anomalies 1 85.28 High High
Vomiting 1 80.44 Quite High
Toxicity 3 75.00 Quite High
Liver Cancer 1 66.84 Quite High
Lipidosis 2 54.32 Quite High
Necrosis 2 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e1-/- mice.
Negative_regulation (lacking) of Gene_expression (expression) of CYP1A2
1) Confidence 0.42 Published 1998 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9772215 Disease Relevance 0.48 Pain Relevance 0.40
In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.
Negative_regulation (inhibits) of Gene_expression (expression) of CYP1A2 in hepatocytes
2) Confidence 0.39 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.17 Pain Relevance 0.29
Furthermore, the expression of two cytochrome P450 enzymes, CYP1A2 and CYP2E1, was almost completely abolished in livers from hepatocyte-specific beta-catenin knockout mice.
Negative_regulation (abolished) of Gene_expression (expression) of CYP1A2 in livers associated with targeted disruption
3) Confidence 0.36 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

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