INT77947

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Context Info
Confidence 0.24
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.23
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
Kupffer cells 1
IL12A (Homo sapiens)
IL12A - R753Q (1)
Pain Link Frequency Relevance Heat
cytokine 83 100.00 Very High Very High Very High
Inflammatory response 16 96.12 Very High Very High Very High
Inflammation 108 90.60 High High
chemokine 29 87.76 High High
pruritus 2 55.52 Quite High
Enkephalin 2 50.00 Quite Low
antagonist 3 28.28 Quite Low
agonist 7 19.72 Low Low
fibrosis 19 5.00 Very Low Very Low Very Low
psoriasis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 64 98.96 Very High Very High Very High
Dermatitis 28 98.02 Very High Very High Very High
INFLAMMATION 122 96.12 Very High Very High Very High
Infection 99 94.56 High High
Opiate Addiction 79 93.52 High High
Hepatitis C Virus Infection 144 91.24 High High
Disease 62 78.80 Quite High
Herpes Simplex Virus 1 76.60 Quite High
Alcoholic Liver Diseases 19 75.60 Quite High
Fibrosis 37 73.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PIAS members are also an important factors in the IL-12-induced IFN-?
Regulation (important) of Gene_expression (factors) of IL-12-induced
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.72 Pain Relevance 0
METHODS: To measure the effects of met-enk on NK activity, the production and gene expression of anti-tumor cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-12 (IL-12) in vitro and in vivo.
Regulation (effects) of Gene_expression (expression) of IL-12
2) Confidence 0.16 Published 1996 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 9772675 Disease Relevance 0 Pain Relevance 0
The up-regulated expression of IL-12p35 found in the present study may indicate an enhanced production of IL-12 and thus may indicate a TH1 response in the treated periodontal tissues.
Regulation (regulated) of Gene_expression (expression) of IL-12p35
3) Confidence 0.08 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.22 Pain Relevance 0.20
1 and IL-10 and down-regulation of TNF and IL-12 production, an impaired disposal of apoptotic hepatocytes by Kupffer cells will negatively affect the anti-inflammatory response of Kupffer cells.
Regulation (regulation) of Gene_expression (production) of IL-12 in Kupffer cells associated with inflammatory response and apoptosis
4) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.41 Pain Relevance 0.29
The role of R753Q in AD has been confirmed in the cytokine-based profiling of patients where stimulation of TLR 2 induced altered production of IL-6 and IL-12 [92].
Regulation (altered) of Gene_expression (production) of IL-12 (R753Q) associated with dermatitis and cytokine
5) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.65 Pain Relevance 0.10
The levels of other cytokines such as IL-2, IL-4, IL-12, IL-13, IL-17, IFN-?
Regulation (levels) of Gene_expression (cytokines) of IL-12 associated with cytokine
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.35

General Comments

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