INT77982

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Context Info
Confidence 0.17
First Reported 1998
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
YY1 (Homo sapiens)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
agonist 1 99.84 Very High Very High Very High
Ultiva 10 99.48 Very High Very High Very High
Opioid 3 95.20 Very High Very High Very High
rapifen 1 90.32 High High
analgesia 1 84.88 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 1 84.00 Quite High
Stress 1 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remifentanil is a pure agonist at the mu opioid receptor with relatively little binding at the kappa, sigma or delta receptors.
delta Neg (little) Binding (binding) of mu opioid receptor associated with mu opioid receptor, agonist and ultiva
1) Confidence 0.17 Published 2005 Journal Expert Opin Drug Saf Section Abstract Doc Link 16011444 Disease Relevance 0.17 Pain Relevance 0.85
Of the various tyrosine derivatives prepared, 5-methyl-6-beta-phenethyl-3-tyrosylaminobutyl-2(1H)-pyrazinone exhibited strong binding to the mu-opioid receptor with a Ki value of 55.8 nM and to the delta-opioid receptor with a Ki value of 2165 nM and with a Ki mu/Ki delta value of 0.026.
delta Binding (binding) of mu-opioid receptor associated with opioid receptor
2) Confidence 0.06 Published 1998 Journal Chem. Pharm. Bull. Section Abstract Doc Link 9775433 Disease Relevance 0 Pain Relevance 0.21

General Comments

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