INT77983

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.91
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Csrp1)
Anatomy Link Frequency
blood 4
joint 4
Csrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 10 99.96 Very High Very High Very High
Inflammatory marker 2 98.98 Very High Very High Very High
Pain 4 97.94 Very High Very High Very High
Migraine 22 97.80 Very High Very High Very High
Inflammation 12 97.20 Very High Very High Very High
methotrexate 35 73.88 Quite High
central sensitization 1 73.60 Quite High
Central nervous system 3 69.52 Quite High
antagonist 2 61.20 Quite High
adenocard 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 25 99.96 Very High Very High Very High
Adhesions 2 99.16 Very High Very High Very High
INFLAMMATION 12 98.82 Very High Very High Very High
Arthralgia 4 97.94 Very High Very High Very High
Headache 23 97.80 Very High Very High Very High
Stress 2 96.24 Very High Very High Very High
Thrombosis 2 95.80 Very High Very High Very High
Body Weight 2 94.92 High High
Hypertension 2 94.40 High High
Hyperlipidemia 2 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With regard to study design, patients were identified retrospectively and our phenotypes were pre-defined using data that was available on all patients (thus ESR and CRP were used as surrogates for defining response rather than formal joint counts that were not available for all patients).
Positive_regulation (thus) of Gene_expression (used) of CRP in joint
1) Confidence 0.19 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.43 Pain Relevance 0.26
The presence of two or three of the following three items in patients with joint pain without any bone and joint destruction was thus indicated to be useful for the early diagnosis of RA: elevated CRP level (> or = 1.0 mg/dl), positive rheumatoid factor (RF) (> or = 30 IU/ml) and an elevated sIL-2R level (> or = 100 pmol/l).
Positive_regulation (elevated) of Gene_expression (level) of CRP in joint associated with pain, arthralgia and rheumatoid arthritis
2) Confidence 0.10 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9776115 Disease Relevance 1.09 Pain Relevance 0.69
Several studies indicate that migraine is associated with special pattern of inflammatory markers and some adverse vascular risk factors including: increased levels of CRP, ILs, TNF-alpha and adhesion molecules which are markers of systemic inflammation, oxidative stress and thrombosis, increased body weight, high blood pressure, hypercholesterolemia, impaired insulin sensitivity, high homocysteine levels, stroke and coronary heart disease.
Positive_regulation (increased) of Gene_expression (levels) of CRP in blood associated with stress, coronary artery disease, body weight, stroke, migraine, thrombosis, inflammation, inflammatory marker, hypertension, hyperlipidemia and adhesions
3) Confidence 0.10 Published 2009 Journal Atherosclerosis Section Abstract Doc Link 19054516 Disease Relevance 1.69 Pain Relevance 0.71
Several studies indicate that migraine is associated with special pattern of inflammatory markers and some adverse vascular risk factors including: increased levels of CRP, ILs, TNF-alpha and adhesion molecules which are markers of systemic inflammation, oxidative stress and thrombosis, increased body weight, high blood pressure, hypercholesterolemia, impaired insulin sensitivity, high homocysteine levels, stroke and coronary heart disease.
Positive_regulation (increased) of Gene_expression (levels) of CRP in blood associated with stress, coronary artery disease, body weight, stroke, migraine, thrombosis, inflammation, inflammatory marker, hypertension, hyperlipidemia and adhesions
4) Confidence 0.07 Published 2009 Journal Atherosclerosis Section Abstract Doc Link 19054516 Disease Relevance 1.69 Pain Relevance 0.71

General Comments

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