INT77991

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Context Info
Confidence 0.06
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.78
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Svs4) extracellular region (Svs4)
Svs4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 50 100.00 Very High Very High Very High
Pain 19 98.88 Very High Very High Very High
tetrodotoxin 1 98.40 Very High Very High Very High
antagonist 22 97.98 Very High Very High Very High
Glutamate 13 92.64 High High
dorsal root ganglion 53 89.20 High High
Locus ceruleus 5 86.72 High High
Action potential 6 84.68 Quite High
Spinal cord 18 80.68 Quite High
Brush evoked pain 3 80.16 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 10 99.48 Very High Very High Very High
Pain 21 98.88 Very High Very High Very High
Ganglion Cysts 77 89.20 High High
Neuropathic Pain 8 80.16 Quite High
Nociception 19 75.40 Quite High
Low Back Pain 1 43.76 Quite Low
INFLAMMATION 25 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When ADP was applied at a low dose, only a single peak of Ca2+ was observed in a fraction of cells.
Gene_expression (applied) of ADP
1) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.04
(b), (d) As expected, the P2Y1 antagonist MRS2179 does not affect the response to UTP but it does not inhibit even that to ADP, outlining the presence of ADP-sensitive receptors other than P2Y1 (n = 59–164)
Gene_expression (presence) of ADP associated with antagonist
2) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.20
To confirm this description, especially the role of P2Y12 in Ca2+ signalling, further studies testing the pharmacological and pertussis toxin sensitivity of the ADP response were carried out.


Gene_expression (response) of ADP associated with bordatella infection
3) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.10 Pain Relevance 0.04
On the other hand, in vivo studies revealed that i.t. administration of the P2Y2/4 agonist UTP and of the P2Y1 agonist ADP-?
Gene_expression (agonist) of ADP associated with agonist
4) Confidence 0.04 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.68 Pain Relevance 0.62
In the presence of tetrodotoxin and a combination of other neurotransmission blockers, both alphabetameATP and alphabetameADP still produced inward currents.
Gene_expression (produced) of alphabetameADP associated with tetrodotoxin
5) Confidence 0.01 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9776383 Disease Relevance 0 Pain Relevance 0.51

General Comments

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