INT7800

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Context Info
Confidence 0.56
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 51
Total Number 52
Disease Relevance 33.06
Pain Relevance 53.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 9
lateral 3
muscle 2
hypothalamus 2
GABAergic neurons 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 525 100.00 Very High Very High Very High
Morphine 309 100.00 Very High Very High Very High
gABA 122 100.00 Very High Very High Very High
substance P 78 100.00 Very High Very High Very High
Rostral ventromedial medulla 73 100.00 Very High Very High Very High
Enkephalin 68 100.00 Very High Very High Very High
Glutamate 58 100.00 Very High Very High Very High
Periaqueductal grey 43 100.00 Very High Very High Very High
Neurotransmitter 5 100.00 Very High Very High Very High
Cholecystokinin 10 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 682 100.00 Very High Very High Very High
Generalized Anxiety Disorder 234 99.76 Very High Very High Very High
Sleep Disorders 168 99.66 Very High Very High Very High
Pain 78 99.66 Very High Very High Very High
INFLAMMATION 53 99.66 Very High Very High Very High
Nociception 80 99.28 Very High Very High Very High
Intractable Pain 2 99.04 Very High Very High Very High
Stress 16 92.56 High High
Pressure And Volume Under Development 6 91.24 High High
Opiate Addiction 3 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that activity of 5-HT in spinal cord and PAG increases with carrageenan inflammation; the carrageenan-induced release of 5-HT and 5-HIAA in spinal cord may be tonically modulated by supraspinal opioid and GABA systems, whereas the release in PAG may only be tonically modulated by endogenous GABA system in supraspinal level.
Localization (release) of PAG in spinal cord associated with gaba, inflammation, opioid, central grey and spinal cord
1) Confidence 0.56 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095514 Disease Relevance 0.89 Pain Relevance 1.11
In vivo microdialysis and antinociceptive testing were simultaneously applied in rats to characterize the effects of morphine on PAG histamine release and determine the relationship between histamine release and antinociception.
Localization (release) of PAG associated with antinociception, central grey, antinociceptive and morphine
2) Confidence 0.50 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7689107 Disease Relevance 0.59 Pain Relevance 1.27
Our study has also investigated the role of PAG mGluR(7) on thermoceptive threshold and PAG glutamate and GABA release.
Localization (release) of PAG associated with gaba, glutamate and central grey
3) Confidence 0.50 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17507496 Disease Relevance 0.63 Pain Relevance 0.78
Probes were inserted into the PAG prior to, during and following muscle contraction in the absence or presence of clonidine. ir-END was released from the PAG up to 3 h after surgery was completed while cats remained at rest.
Localization (released) of PAG in muscle associated with periaqueductal grey and clonidine
4) Confidence 0.48 Published 1994 Journal Neuropeptides Section Abstract Doc Link 8159281 Disease Relevance 0.51 Pain Relevance 0.68
These data suggest that isometric contractions of skeletal muscle do not induce the release of ir-END-like substances from the PAG and clonidine does not attenuate the muscle pressor response by causing the release of ir-END from this level in the PAG.
Localization (release) of PAG in muscle associated with periaqueductal grey and clonidine
5) Confidence 0.48 Published 1994 Journal Neuropeptides Section Abstract Doc Link 8159281 Disease Relevance 0.64 Pain Relevance 0.75
The results showed that: (1) pain stimulation elevated AVP concentration in both PVN and PAG perfusion liquid, in which the peak of AVP concentration in PVN perfusion liquid occurred earlier than that in PAG perfusion liquid; (2) PVN cauterization weakened pain stimulation-induced PAG releasing AVP, in which the inhibitive effect of bilateral PVN cauterization showed stronger than that of unilateral PVN cauterization; (3) microinjection of l-glutamate sodium into PVN, which excited local neurons, increased AVP concentration in PAG perfusion liquid in a dose-dependent manner.
Localization (releasing) of PAG in neurons associated with pain, glutamate and central grey
6) Confidence 0.38 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123712 Disease Relevance 1.24 Pain Relevance 1.15
g) from the PAG of mice were separated and electrotransferred onto PDVF membranes (Invitrogen), which were probed with anti-NR2A, anti-NR2B, anti-GluR1 (Chemicon), and with ?
Localization (electrotransferred) of PAG associated with central grey
7) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.64 Pain Relevance 0.47
g) from the PAG of mice were separated and electrotransferred onto PDVF membranes (Invitrogen), which were probed with anti-NR2A, anti-NR2B, anti-GluR1 (Chemicon), and with ?
Localization (separated) of PAG associated with central grey
8) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.64 Pain Relevance 0.47
Since cataplexy was not affected it is possible that neurons regulating muscle tone were not lesioned (since they do not contain the HCRT receptor) or that the cataplexy neurons are not located in the vlPAG.
Localization (located) of vlPAG in neurons associated with sleep disorders
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.59 Pain Relevance 0.07
Next, we determined that the vlPAG was innervated by HCRT neurons.
Localization (innervated) of vlPAG in neurons
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.40 Pain Relevance 0.08
DOR in the PAG of morphine tolerant rats could be a compensatory mechanism for
Localization (mechanism) of PAG associated with urological neuroanatomy and morphine
11) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.85 Pain Relevance 1.55
However, DORs are located in the PAG [13] and these receptors
Localization (located) of PAG associated with urological neuroanatomy and delta opioid receptors
12) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.66 Pain Relevance 1.55
VIP mRNA-producing neurones were found in very localized regions of the PAG, including the cell-sparse region immediately ventral to the aqueduct and the ventral part of the dorsal raphe nucleus.
Localization (localized) of PAG in ventral associated with urological neuroanatomy and raphe
13) Confidence 0.34 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7860799 Disease Relevance 0.90 Pain Relevance 1.02
In 8 of 11 mice HCRT2-SAP (16.5 ng/23 nl) induced lesions were localized to the vlPAG (fig. 1A-H).
Localization (localized) of vlPAG
14) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0 Pain Relevance 0
Also, deep brain stimulation targeting PAG has been used to treat intractable pain for over 50 years.
Localization (targeting) of PAG in brain associated with deep brain stimulation, intractable pain and periaqueductal grey
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 1.18 Pain Relevance 2.25
Rats were implanted with an osmotic minipump that released morphine (2.5 or 5 microg/h) or saline into the vPAG continuously.
Localization (released) of vPAG associated with morphine
16) Confidence 0.27 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051146 Disease Relevance 0.30 Pain Relevance 1.48
Except for taurine, no significant difference in veratridine-induced release between the lateral and medial PAG was observed.
Localization (release) of PAG in lateral associated with central grey
17) Confidence 0.26 Published 1992 Journal Brain Res. Section Abstract Doc Link 1450948 Disease Relevance 0.62 Pain Relevance 1.16
The current study examined the effects of electroacupuncture at Zusanli (ST36) and Shangjuxu (ST37) acupoints, which are used for clinical pain control, on the release of neurotransmitters in the PAG in rats.
Localization (release) of PAG associated with pain, neurotransmitter, central grey and electroacupuncture
18) Confidence 0.26 Published 2010 Journal Brain Res. Section Abstract Doc Link 19819232 Disease Relevance 0.93 Pain Relevance 1.61
Cellular Ca(2+) fluorescence measurement using fura-2 indicated that neurotensin rapidly induced Ca(2+) release from intracellular stores of PAG-RVM neurons.
Localization (release) of PAG-RVM in RVM associated with central grey and rostral ventromedial medulla
19) Confidence 0.21 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11287471 Disease Relevance 0.94 Pain Relevance 1.44
Significant increases in GFAP immunoreactivity were localized histologically to the lateral and caudal ventrolateral columns of the PAG.
Localization (localized) of PAG in lateral associated with central grey
20) Confidence 0.19 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.26 Pain Relevance 0.94

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