INT78003

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Context Info
Confidence 0.26
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
nucleus 2
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 6 97.32 Very High Very High Very High
Spinal cord 4 93.80 High High
Dorsal horn 1 77.76 Quite High
unmyelinated 1 75.32 Quite High
Deafferentation 2 75.00 Quite High
5HT 1 69.44 Quite High
gABA 6 67.56 Quite High
Dopamine 17 46.64 Quite Low
opioid receptor 3 23.48 Low Low
Opioid 4 6.40 Low Low
Disease Link Frequency Relevance Heat
Disease 41 94.08 High High
Parkinson's Disease 23 87.68 High High
Generalized Anxiety Disorder 5 79.00 Quite High
Repression 1 75.00 Quite High
Dyskinesias 43 44.16 Quite Low
Wheal 1 8.24 Low Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low
Dystonia 2 5.00 Very Low Very Low Very Low
Chorea 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats, an ipsilateral marked up-regulation of GAD65/67 mRNA expression in the ENT nucleus has been reported following 6-OHDA lesion (Soghomonian and Chesselet, 1992; Barroso-Chinea et al., 2008).
Regulation (regulation) of Transcription (expression) of GAD65 in nucleus
1) Confidence 0.26 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.47 Pain Relevance 0
In contrast, GAD65 mRNA levels remained low and were unaffected by the treatment, and EP10 was not detected.
Neg (unaffected) Regulation (unaffected) of Transcription (levels) of GAD65
2) Confidence 0.18 Published 1998 Journal Perspect Dev Neurobiol Section Abstract Doc Link 9777631 Disease Relevance 0.15 Pain Relevance 0.81

General Comments

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