INT7801

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Context Info
Confidence 0.32
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.96
Pain Relevance 8.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 4
lateral 2
muscle 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 43 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
Periaqueductal grey 8 100.00 Very High Very High Very High
withdrawal 7 100.00 Very High Very High Very High
Enkephalin 13 99.80 Very High Very High Very High
Clonidine 5 99.80 Very High Very High Very High
Pain 14 99.74 Very High Very High Very High
Opioid 8 99.24 Very High Very High Very High
antinociception 11 98.96 Very High Very High Very High
Morphine 22 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 57 100.00 Very High Very High Very High
Pain 9 99.74 Very High Very High Very High
Nociception 4 99.28 Very High Very High Very High
Opiate Addiction 3 91.32 High High
INFLAMMATION 3 87.52 High High
Injury 6 85.24 High High
Hyperalgesia 1 74.04 Quite High
Neuropathic Pain 2 73.36 Quite High
Substance Withdrawal Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that isometric contractions of skeletal muscle do not induce the release of ir-END-like substances from the PAG and clonidine does not attenuate the muscle pressor response by causing the release of ir-END from this level in the PAG.
Neg (not) Positive_regulation (induce) of Localization (release) of PAG in muscle associated with periaqueductal grey and clonidine
1) Confidence 0.32 Published 1994 Journal Neuropeptides Section Abstract Doc Link 8159281 Disease Relevance 0.64 Pain Relevance 0.75
The results showed that: (1) pain stimulation elevated AVP concentration in both PVN and PAG perfusion liquid, in which the peak of AVP concentration in PVN perfusion liquid occurred earlier than that in PAG perfusion liquid; (2) PVN cauterization weakened pain stimulation-induced PAG releasing AVP, in which the inhibitive effect of bilateral PVN cauterization showed stronger than that of unilateral PVN cauterization; (3) microinjection of l-glutamate sodium into PVN, which excited local neurons, increased AVP concentration in PAG perfusion liquid in a dose-dependent manner.
Positive_regulation (induced) of Localization (releasing) of PAG in neurons associated with pain, glutamate and central grey
2) Confidence 0.25 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123712 Disease Relevance 1.24 Pain Relevance 1.16
Significant increases in GFAP immunoreactivity were localized histologically to the lateral and caudal ventrolateral columns of the PAG.
Positive_regulation (increases) of Localization (localized) of PAG in lateral associated with central grey
3) Confidence 0.13 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.28 Pain Relevance 0.95
We suggest that an increased release of SP in the PAG may contribute to opioid antinociception.
Positive_regulation (increased) of Localization (release) of PAG associated with antinociception, opioid, central grey and substance p
4) Confidence 0.10 Published 2004 Journal Brain Res. Section Abstract Doc Link 14972657 Disease Relevance 0.62 Pain Relevance 1.62
In addition, we confirmed in normal animals that the ventrolateral PAG is induced to release Met-enkephalin by systemic morphine.
Positive_regulation (induced) of Localization (release) of PAG associated with enkephalin, central grey and morphine
5) Confidence 0.08 Published 1995 Journal Brain Res. Section Abstract Doc Link 8535838 Disease Relevance 0.93 Pain Relevance 1.74
Taken with previous studies showing that: (1) both MOR and histamine (HA) induce antinociception when given into the PAG/DR, and (2) systemic MOR releases HA in the PAG, the present results strongly suggest that systemic MOR attenuates supraspinally organized responses to phasic, thermal nociceptive stimuli by mechanisms that include PAG HA release and subsequent activation of PAG H2 receptors.
Positive_regulation (activation) of Localization (release) of PAG associated with nociception, antinociception, urological neuroanatomy and morphine
6) Confidence 0.07 Published 1992 Journal Brain Res. Section Abstract Doc Link 1356588 Disease Relevance 0.65 Pain Relevance 1.17
Inhibition of GAT-1 or PKA also prevented withdrawal-induced hyperexcitation of PAG neurons.
Positive_regulation (withdrawal-induced) of Localization (hyperexcitation) of PAG in neurons associated with central grey and withdrawal
7) Confidence 0.04 Published 2005 Journal Neuron Section Abstract Doc Link 15694329 Disease Relevance 0.60 Pain Relevance 1.29

General Comments

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