INT78023

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 18
Disease Relevance 23.55
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DDX41) RNA binding (DDX41) nucleus (DDX41)
helicase activity (DDX41)
Anatomy Link Frequency
cerebrospinal fluid 2
macrophages 1
Plasma 1
microglial cells 1
DDX41 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 100 99.44 Very High Very High Very High
Demyelination 42 98.48 Very High Very High Very High
Opioid 4 97.68 Very High Very High Very High
imagery 16 97.08 Very High Very High Very High
headache 22 96.68 Very High Very High Very High
idiopathic sensory neuropathy 1 96.68 Very High Very High Very High
Sicca syndrome 18 96.04 Very High Very High Very High
Neuritis 66 95.72 Very High Very High Very High
corticosteroid 7 86.40 High High
Angina 2 84.24 Quite High
Disease Link Frequency Relevance Heat
Syndrome 154 100.00 Very High Very High Very High
Growth Hormone Deficiency 1 100.00 Very High Very High Very High
Neuromyelitis Optica 566 99.90 Very High Very High Very High
Cold Sores 406 99.76 Very High Very High Very High
Chronic Fatigue Syndrome 2 99.56 Very High Very High Very High
Infection 185 99.52 Very High Very High Very High
Demyelinating Disease 172 99.44 Very High Very High Very High
Neurological Disease 54 99.12 Very High Very High Very High
Systemic Lupus Erythematosus 91 98.84 Very High Very High Very High
Arrhythmias 2 Under Development 15 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-Hu antibodies (Hu-Abs) were positive in 40 patients with paraneoplastic sensory neuropathy (PSN) and in 1 patient with idiopathic sensory neuropathy in a series of 126 patients who presented with clinical features suggestive of PSN.
Gene_expression (positive) of Abs associated with idiopathic sensory neuropathy and neuropathic pain
1) Confidence 0.65 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9851446 Disease Relevance 0.84 Pain Relevance 0.10
The mean levels of ACL Abs were 38.8+/-28.2 GPL (normal values up to 7.5).
Gene_expression (levels) of Abs
2) Confidence 0.58 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9778261 Disease Relevance 1.51 Pain Relevance 0.54
We conclude that patients with probable or definite diagnosis of MS, and consistently elevated levels of ACL Abs show a slower progression and some atypical (for MS) features, such as persistent headaches and absence of oligoclonal bands in the cerebrospinal fluid.
Gene_expression (levels) of Abs in cerebrospinal fluid associated with multiple sclerosis and headache
3) Confidence 0.58 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9778261 Disease Relevance 1.25 Pain Relevance 0.44
Following resuscitation, a diagnosis of ABS was made.
Gene_expression (diagnosis) of ABS associated with syndrome
4) Confidence 0.54 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2490812 Disease Relevance 1.45 Pain Relevance 0.08
Additionally, serum Abs to full length AQP4 were also detected in the patient with isolated myelitis, but not in the patient with SLE-myelitis, who were both positive for M-23 AQP4-IgG.
Neg (not) Gene_expression (detected) of Abs associated with systemic lupus erythematosus and demyelinating disease
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 2.06 Pain Relevance 0.21
In contrast, AQP4-IgG Abs were not present in patients with MS, OND, and non-neuropsychiatric SLE and in HC, which supports their high relevance as biological markers.
Neg (not) Gene_expression (present) of Abs associated with multiple sclerosis, neurological disease and systemic lupus erythematosus
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.99 Pain Relevance 0.19
Increased cellularity (89 cells/mm3) and anti-cysticercal antibodies (Abs) determined by ELISA were detected in the cerebrospinal fluid (CSF).
Gene_expression (detected) of Abs in cerebrospinal fluid
7) Confidence 0.20 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2841125 Disease Relevance 0.73 Pain Relevance 0.35
In contrast, IgM anti-AQP4 Abs were not only found in some NMO and high risk patients, but also in controls.
Gene_expression (found) of Abs associated with neuromyelitis optica
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 2.65 Pain Relevance 0.20
NMO-IgG Abs have also been detected in patients with non organ specific autoimmunity such as in systemic lupus erythematosus (SLE) or Sjögren syndrome (SS) patients [16].
Gene_expression (detected) of Abs associated with neuromyelitis optica, autoimmune disease, syndrome, sicca syndrome and systemic lupus erythematosus
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 3.33 Pain Relevance 0.55
Our assay with living AQP4 M-23 transfected cells is highly sensitive for detecting anti-AQP4-IgG Abs in definite (97%) and high risk (65%) NMO patients.
Gene_expression (detecting) of Abs associated with neuromyelitis optica
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.89 Pain Relevance 0.19
Serum anti-AQP4 M-23 IgG Abs were specifically detected in 29 NMO patients, 17 patients with high risk NMO and two patients with myelitis due to demyelination (CIS) and SLE.
Gene_expression (detected) of Abs associated with neuromyelitis optica, demyelination, systemic lupus erythematosus and demyelinating disease
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 2.55 Pain Relevance 0.21
Although the large majority of men (and women) receiving opioids do develop hypogonadism, about 15 percent also develop central hypocorticism and 15 percent develop growth hormone deficiency (Abs et al 2000).


Gene_expression (deficiency) of Abs associated with hypogonadotropic hypogonadism, growth hormone deficiency and opioid
12) Confidence 0.14 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 1.36 Pain Relevance 0.67
The Australian Bureau of Statistics (ABS) does not produce a separate ERP figure for the Indigenous population in private dwellings, so the only other option using ABS data is to use census counts of people in private dwellings as the basis of comparison.
Neg (not) Gene_expression (produce) of ABS
13) Confidence 0.06 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1373687 Disease Relevance 0.18 Pain Relevance 0
HSV-2 specific Abs were detected by HerpeSelect 2 ELISA IgG (Focus Diagnostic, Cypress, CA).


Gene_expression (detected) of Abs associated with cold sores
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.20 Pain Relevance 0
Double stainings with Abs anti-LMP2 and anti-CD68 (Dako, Carpintera, CA, USA, diluted 1?
Gene_expression (stainings) of Abs
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.53 Pain Relevance 0
Furthermore, we performed IHC double staining with Abs anti-CD68 (marker of microglial cells and macrophages) and anti-LMP2 (or anti-PA28-??)
Gene_expression (anti) of Abs in microglial cells
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.41 Pain Relevance 0.05
Plasma samples obtained at the indicated times after infection were monitored for the presence of SIV envelope Abs by using an established ELISA protocol [38].
Gene_expression (presence) of Abs in Plasma associated with infection
17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.20 Pain Relevance 0
Furthermore, we performed IHC double staining with Abs anti-CD68 (marker of microglial cells and macrophages) and anti-LMP2 (or anti-PA28-??)
Gene_expression (anti) of Abs in macrophages
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.41 Pain Relevance 0.05

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