INT78024

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 73
Total Number 75
Disease Relevance 59.15
Pain Relevance 18.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACLY) mitochondrion (ACLY) small molecule metabolic process (ACLY)
nucleolus (ACLY) plasma membrane (ACLY) nucleus (ACLY)
Anatomy Link Frequency
knee 4
coronary artery 2
ACL 2
joint 2
anterior 1
ACLY (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1343 100.00 Very High Very High Very High
dexamethasone 65 100.00 Very High Very High Very High
Osteoarthritis 186 99.74 Very High Very High Very High
spinal inflammation 661 99.70 Very High Very High Very High
Multiple sclerosis 136 99.44 Very High Very High Very High
Infliximab 1087 99.36 Very High Very High Very High
Pain 166 98.96 Very High Very High Very High
Adalimumab 132 98.96 Very High Very High Very High
imagery 171 98.32 Very High Very High Very High
Inflammation 197 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1343 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 836 100.00 Very High Very High Very High
Injury 686 100.00 Very High Very High Very High
Rupture 168 100.00 Very High Very High Very High
Cardiovascular Disease 119 100.00 Very High Very High Very High
Fatigue 29 100.00 Very High Very High Very High
Generalized Epilepsy 6 99.80 Very High Very High Very High
Synovitis 34 99.78 Very High Very High Very High
Thrombosis 295 99.76 Very High Very High Very High
Epilepsy 66 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that patients with probable or definite diagnosis of MS, and consistently elevated levels of ACL Abs show a slower progression and some atypical (for MS) features, such as persistent headaches and absence of oligoclonal bands in the cerebrospinal fluid.
Gene_expression (levels) of ACL in cerebrospinal fluid associated with multiple sclerosis and headache
1) Confidence 0.75 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9778261 Disease Relevance 1.25 Pain Relevance 0.44
In addition, a number of studies have also documented that the intrinsic healing capacities, cellular proliferation, and extracellular matrix (ECM) production of the ACL are also lower compared to the MCL [24,178,179,181,184-188].
Gene_expression (production) of ACL in extracellular matrix associated with hyperplasia
2) Confidence 0.64 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2695438 Disease Relevance 0.44 Pain Relevance 0
Operation treatment evaluation – intra-operative assessment of ACL reconstruction
Gene_expression (reconstruction) of ACL
3) Confidence 0.59 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2744659 Disease Relevance 0.05 Pain Relevance 0
Contribution of knee stability assessment at different stages of ACL injury
Gene_expression (injury) of ACL in knee associated with injury
4) Confidence 0.59 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2744659 Disease Relevance 0.66 Pain Relevance 0
It has two basic components for ACL reconstruction:

• A set of optical camera to locate the surgical joint and limb, and to create a picture or image of the operation site. • Computer programs which integrate these images with surgical information and assist the surgeon during the operation.

Gene_expression (reconstruction) of ACL in limb
5) Confidence 0.59 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2744659 Disease Relevance 0 Pain Relevance 0
In cadaveric study, it is also suggested that an isolated excision of ACL would increase anterior drawer and tibial rotation in both flexion and extension [26].
Gene_expression (excision) of ACL in anterior
6) Confidence 0.59 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2744659 Disease Relevance 0.64 Pain Relevance 0
The ACL graft was found to be well fixed, but small areas of chondral damage were found in the patellofemoral and medial compartment.
Gene_expression (graft) of ACL in ACL
7) Confidence 0.59 Published 2009 Journal Orthopedics Section Abstract Doc Link 19309052 Disease Relevance 0.44 Pain Relevance 0.19
According to both radiological classifications, there is a significant difference (p < 0.05) in development of OA between the ACL injured and subsequently operated knee in comparison to contralateral knee.
Gene_expression (injured) of ACL in knee associated with osteoarthritis
8) Confidence 0.59 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2430704 Disease Relevance 0.81 Pain Relevance 0.13
In this study ACL reconstruction was not able to prevent radiological knee OA despite the fact that the patients with the most severe osteoarthritis, the patients who received a knee arthroplasty, were excluded in this study.
Gene_expression (reconstruction) of ACL in knee associated with osteoarthritis
9) Confidence 0.59 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2430704 Disease Relevance 1.00 Pain Relevance 0.41
In this study a subgroup analysis to evaluate differences in outcomes measurements for different ages at time of ACL rupture was not realistic
Gene_expression (rupture) of ACL associated with rupture
10) Confidence 0.59 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2430704 Disease Relevance 1.18 Pain Relevance 0.37
A developing trend for ACL reconstruction
Gene_expression (reconstruction) of ACL
11) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
Discovery of tools for biomechanical studies of the ACL and ACL grafts
Gene_expression (studies) of ACL
12) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0.40 Pain Relevance 0
Discovery of tools for biomechanical studies of the ACL and ACL grafts
Gene_expression (studies) of ACL
13) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0.39 Pain Relevance 0
Future roles of biomechanics in ACL reconstruction
Gene_expression (reconstruction) of ACL
14) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
Anatomy and biomechanics of the ACL
Gene_expression (Anatomy) of ACL in Anatomy
15) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
Biomechanics for ACL reconstruction
Gene_expression (reconstruction) of ACL
16) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
BPTB autografts have been proclaimed as the "gold standard" in ACL reconstruction.
Gene_expression (reconstruction) of ACL
17) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0.09 Pain Relevance 0.09
ACL reconstruction
Gene_expression (reconstruction) of ACL
18) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
Factors affecting the outcome of an ACL reconstruction
Gene_expression (reconstruction) of ACL
19) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
As such, surgical reconstruction of the ACL has not been able to reproduce its complex function.
Gene_expression (reconstruction) of ACL
20) Confidence 0.58 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0.14 Pain Relevance 0.04

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