INT78033

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.50
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
uterine 6
smooth muscle cells 4
myometrium 2
supraoptic nucleus 2
neurosecretory cells 2
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 24 99.98 Very High Very High Very High
agonist 12 99.78 Very High Very High Very High
Morphine 36 99.76 Very High Very High Very High
narcan 12 99.48 Very High Very High Very High
Dismenorea 5 95.52 Very High Very High Very High
antagonist 8 95.32 Very High Very High Very High
Intracerebroventricular 3 90.20 High High
addiction 6 90.08 High High
Opioid 3 85.80 High High
anesthesia 2 54.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 3 99.36 Very High Very High Very High
Premature Birth 2 98.60 Very High Very High Very High
Uterine Fibroids 9 97.20 Very High Very High Very High
Dysmenorrhea 5 95.52 Very High Very High Very High
Endometrial Stromal Sarcoma 7 85.48 High High
Leiomyosarcoma 5 84.84 Quite High
Smooth Muscle Tumor 3 75.00 Quite High
Metaplasia 1 71.12 Quite High
Nicotine Addiction 3 51.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Positive_regulation (activation) of Gene_expression (expression) of OTR gene in smooth muscle cells associated with antagonist
1) Confidence 0.70 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
It was concluded that the enhanced expression of OTR mRNA induced by Beta(2)-agonists in the late-pregnant rat uterus may be a possible drawback to effective therapy of preterm uterine contractions with Beta(2)-agonists.
Positive_regulation (enhanced) of Gene_expression (expression) of OTR mRNA in uterine associated with dismenorea and agonist
2) Confidence 0.69 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0.10 Pain Relevance 0.27
It was concluded that the enhanced expression of OTR mRNA induced by Beta(2)-agonists in the late-pregnant rat uterus may be a possible drawback to effective therapy of preterm uterine contractions with Beta(2)-agonists.
Positive_regulation (induced) of Gene_expression (expression) of OTR mRNA in uterine associated with dismenorea and agonist
3) Confidence 0.69 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0.10 Pain Relevance 0.27
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Positive_regulation (activation) of Gene_expression (synthesis) of OTR in smooth muscle cells associated with antagonist
4) Confidence 0.61 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
These findings suggest that CSE directly increases the contractile sensitivity of preterm myometrium in response to OT by upregulating the expression of OTR mRNA and thereby increases the risk of preterm delivery in women, who smoke during pregnancy.
Positive_regulation (upregulating) of Gene_expression (expression) of OTR mRNA in myometrium associated with premature birth
5) Confidence 0.50 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.15 Pain Relevance 0
We measured stimulation of c-fos and oxytocin gene expression during excitation of oxytocin cells induced by systemic or local morphine withdrawal.
Positive_regulation (stimulation) of Gene_expression (expression) of oxytocin gene associated with withdrawal and morphine
6) Confidence 0.45 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10648731 Disease Relevance 0 Pain Relevance 0.85
Beta 2-agonist treatment enhances uterine oxytocin receptor mRNA expression in pregnant rats.
Positive_regulation (enhances) of Gene_expression (expression) of uterine oxytocin receptor mRNA in uterine associated with agonist
7) Confidence 0.43 Published 2004 Journal Mol. Reprod. Dev. Section Title Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.22
Thus, morphine withdrawal excitation increases c-fos and oxytocin gene expression in supraoptic nucleus neurons.
Positive_regulation (increases) of Gene_expression (expression) of oxytocin gene in supraoptic nucleus associated with withdrawal and morphine
8) Confidence 0.32 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10648731 Disease Relevance 0 Pain Relevance 1.08
Local morphine withdrawal increases c-fos gene, Fos protein, and oxytocin gene expression in hypothalamic magnocellular neurosecretory cells.
Positive_regulation (increases) of Gene_expression (expression) of oxytocin gene in neurosecretory cells associated with narcan, withdrawal and morphine
9) Confidence 0.32 Published 2000 Journal J. Neurosci. Section Title Doc Link 10648731 Disease Relevance 0 Pain Relevance 1.18
Five cases of LMS showed moderate to strong OTR expression in 100% of the tumor cells, whereas three cases were weakly positive in 10-20% of the tumor cells.
Positive_regulation (strong) of Gene_expression (expression) of OTR associated with cancer
10) Confidence 0.24 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14576480 Disease Relevance 2.16 Pain Relevance 0.09

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