INT78034

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Context Info
Confidence 0.81
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 1.09
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
smooth muscle cells 2
endometrium 1
stomach 1
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 11 97.00 Very High Very High Very High
amygdala 20 96.44 Very High Very High Very High
agonist 120 94.00 High High
antagonist 195 89.80 High High
Anterior cingulate 5 88.36 High High
anesthesia 3 79.84 Quite High
Hippocampus 20 73.36 Quite High
Cholecystokinin 1 65.92 Quite High
Neuropeptide 30 55.84 Quite High
depression 15 53.92 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 5 97.00 Very High Very High Very High
Reprotox - General 1 2 75.00 Quite High
Anxiety Disorder 40 72.64 Quite High
Mental Disorders 5 70.40 Quite High
Death 5 67.12 Quite High
Autism 30 54.80 Quite High
Depression 15 53.92 Quite High
Cognitive Disorder 15 17.92 Low Low
Stress 60 5.00 Very Low Very Low Very Low
Targeted Disruption 50 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, OTR and OTR mRNA were localized in smooth muscle cells and in epithelial cells of rat cervix.
Localization (localized) of OTR mRNA in smooth muscle cells
1) Confidence 0.81 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
In conclusion, OTR and OTR mRNA were localized in smooth muscle cells and in epithelial cells of rat cervix.
Localization (localized) of OTR in smooth muscle cells
2) Confidence 0.75 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
The present studies utilized in situ hybridization and immunocytochemistry to localize OTR mRNA and protein distribution in cervices of nonpregnant ovariectomized (OVX) rats and examined the effect of combined and independent treatments with estradiol and progesterone on cervical OTR.
Localization (localize) of OTR mRNA
3) Confidence 0.71 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.08
Western blot and immunohistochemistry methods were used to localize OTR in stomach.
Localization (localize) of OTR in stomach
4) Confidence 0.70 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309416 Disease Relevance 0 Pain Relevance 0.06
A different approach to the assessment of OTR localization utilizes immunocytochemistry.
Localization (localization) of OTR
5) Confidence 0.52 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.20 Pain Relevance 0.11
Therefore, designing drugs targeting both the oxytocin receptor and selectively one specific pathway (by combining agents or addressing one particular cell type for instance) might become a major consideration in the development of the next oxytocin-based therapies.


Localization (targeting) of oxytocin receptor
6) Confidence 0.48 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.03
They appear to be useful tools to investigate receptor localization, desensitization and internalization of the oxytocin receptor ligand.
Spec (investigate) Localization (localization) of oxytocin receptor
7) Confidence 0.46 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.27
For a complete overview on OTR with a special emphasis on OTR localization, the readers are advised to refer to the outstanding review of Gimpl and Fahrenholz [32].


Localization (localization) of OTR
8) Confidence 0.45 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.25 Pain Relevance 0.15
Either strategy provided evidence for the co-precipitation of Myc- or Flag-tagged OTR respectively.
Localization (precipitation) of OTR
9) Confidence 0.43 Published 2003 Journal J. Mol. Endocrinol. Section Abstract Doc Link 14664707 Disease Relevance 0.06 Pain Relevance 0.06
For a complete overview on OTR with a special emphasis on OTR localization, the readers are advised to refer to the outstanding review of Gimpl and Fahrenholz [32].


Localization (localization) of OTR
10) Confidence 0.42 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.25 Pain Relevance 0.15
Microscopic evaluation assessed the presence and localization of OTR and TRPV1 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with adenomyosis and compared them with normal endometrium.
Localization (localization) of OTR in endometrium
11) Confidence 0.21 Published 2010 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 20096818 Disease Relevance 0.09 Pain Relevance 0
OBJECTIVE: We sought to investigate the expression and localization of oxytocin receptor (OTR) and transient receptor potential vanilloid type 1 (TRPV1) in women with and without adenomyosis.
Spec (investigate) Localization (localization) of OTR associated with dismenorea
12) Confidence 0.19 Published 2010 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 20096818 Disease Relevance 0.25 Pain Relevance 0.25

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