INT78035

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.26
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
mammary gland 4
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 40 100.00 Very High Very High Very High
Dismenorea 2 93.80 High High
anesthesia 3 80.40 Quite High
agonist 24 51.92 Quite High
Spinal cord 8 5.00 Very Low Very Low Very Low
Antinociceptive 8 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Dorsal horn 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 93.80 High High
Shock 2 90.76 High High
Stress 12 48.64 Quite Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Progesterone alone had no effect on OTR mRNA expression; however, progesterone combined with estradiol significantly inhibited the up-regulation of OTR mRNA by estradiol alone.
Neg (no) Regulation (had) of Gene_expression (expression) of OTR mRNA
1) Confidence 0.62 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.08
In summary, our data demonstrate a differential control of OTR expression in uterus versus mammary gland and a mammary gland-specific OTR mRNA polyadenylation site.
Regulation (control) of Gene_expression (expression) of OTR in mammary gland
2) Confidence 0.62 Published 2001 Journal J. Mol. Endocrinol. Section Abstract Doc Link 11564602 Disease Relevance 0 Pain Relevance 0
Oxytocin receptor gene expression in rat mammary gland: structural characterization and regulation.
Regulation (regulation) of Gene_expression (expression) of Oxytocin receptor gene in mammary gland
3) Confidence 0.45 Published 2001 Journal J. Mol. Endocrinol. Section Title Doc Link 11564602 Disease Relevance 0.09 Pain Relevance 0.09
2AR antagonists are able to allosterically modulate oxytocin receptor signaling and oxytocin receptor trafficking and, vice versa, an oxytocin antagonist can modulate ?
Regulation (modulate) of Gene_expression (trafficking) of oxytocin receptor associated with antagonist
4) Confidence 0.29 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.13
Progesterone alone had no effect on OTR mRNA expression; however, progesterone combined with estradiol significantly inhibited the up-regulation of OTR mRNA by estradiol alone.
Neg (no) Regulation (effect) of Gene_expression (expression) of OTR mRNA
5) Confidence 0.27 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.08
We also examined the regulatory effects of estrogen and progesterone on OTR mRNA expression in ovariectomized nonpregnant sheep.
Spec (examined) Regulation (effects) of Gene_expression (expression) of OTR
6) Confidence 0.20 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

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