INT78037

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.26
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
smooth muscle cells 4
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 1 99.84 Very High Very High Very High
antagonist 40 99.72 Very High Very High Very High
agonist 28 94.24 High High
Dismenorea 1 58.56 Quite High
anesthesia 4 54.44 Quite High
Intracerebroventricular 2 44.04 Quite Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Antinociceptive 8 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 75.00 Quite High
Diabetes Mellitus 4 58.12 Quite High
Hypertension 1 27.20 Quite Low
Stress 12 18.56 Low Low
Natriuresis 1 11.84 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hexoprenaline induced a maximum 24% increase of OTR mRNA.
Positive_regulation (induced) of Positive_regulation (increase) of OTR mRNA
1) Confidence 0.69 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.20
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Positive_regulation (activation) of Positive_regulation (increased) of OTR in smooth muscle cells associated with antagonist
2) Confidence 0.41 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Positive_regulation (acted) of Positive_regulation (increased) of OTR in smooth muscle cells associated with antagonist
3) Confidence 0.41 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
OTR activation leads to the stimulation of phospholipase A2 production and an increase in cyclooxygenase 2 levels, both resulting in increased prostaglandin production.
Positive_regulation (increase) of Positive_regulation (activation) of OTR associated with cox2
4) Confidence 0.32 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.11 Pain Relevance 0.05
Mechanical stretch appears largely responsible for increased OTR mRNA and to a lesser degree PGHS2 mRNA.
Spec (appears) Positive_regulation (responsible) of Spec (appears) Positive_regulation (increased) of OTR
5) Confidence 0.23 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.07 Pain Relevance 0
In addition, endocrine factors may be required for full activation of OTR and PGHS2 mRNA associated with labor.
Spec (may) Positive_regulation (required) of Positive_regulation (activation) of OTR
6) Confidence 0.21 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.07 Pain Relevance 0

General Comments

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