INT78038

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 43
Total Number 54
Disease Relevance 18.72
Pain Relevance 9.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
uterine smooth muscle 4
smooth muscle 4
uterine 4
mammary gland 3
horn 3
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 347 100.00 Very High Very High Very High
Dismenorea 38 99.96 Very High Very High Very High
Dynorphin 11 99.78 Very High Very High Very High
agonist 184 99.60 Very High Very High Very High
withdrawal 31 99.36 Very High Very High Very High
Enkephalin 9 99.20 Very High Very High Very High
Morphine 36 99.14 Very High Very High Very High
narcan 33 98.70 Very High Very High Very High
GABAergic 26 97.48 Very High Very High Very High
Potency 1 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 10 100.00 Very High Very High Very High
Dysmenorrhea 27 99.96 Very High Very High Very High
Uterine Fibroids 72 99.70 Very High Very High Very High
Endometrial Stromal Sarcoma 56 99.70 Very High Very High Very High
Smooth Muscle Tumor 24 99.50 Very High Very High Very High
Cancer 59 99.36 Very High Very High Very High
Premature Birth 17 98.60 Very High Very High Very High
Breast Cancer 5 98.40 Very High Very High Very High
Leiomyosarcoma 40 97.20 Very High Very High Very High
Nociception 23 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Gene_expression (expression) of OTR gene in smooth muscle cells associated with antagonist
1) Confidence 0.78 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.05
Progesterone alone had no effect on OTR mRNA expression; however, progesterone combined with estradiol significantly inhibited the up-regulation of OTR mRNA by estradiol alone.
Gene_expression (expression) of OTR mRNA
2) Confidence 0.78 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.08
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Gene_expression (expression) of OTR gene in smooth muscle cells associated with antagonist
3) Confidence 0.78 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
In summary, our data demonstrate a differential control of OTR expression in uterus versus mammary gland and a mammary gland-specific OTR mRNA polyadenylation site.
Gene_expression (expression) of OTR in mammary gland
4) Confidence 0.78 Published 2001 Journal J. Mol. Endocrinol. Section Abstract Doc Link 11564602 Disease Relevance 0 Pain Relevance 0
Oxytocin receptor gene expression in rat mammary gland: structural characterization and regulation.
Gene_expression (expression) of Oxytocin receptor gene in mammary gland
5) Confidence 0.78 Published 2001 Journal J. Mol. Endocrinol. Section Title Doc Link 11564602 Disease Relevance 0.09 Pain Relevance 0.09
Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats.
Gene_expression (expressed) of Oxytocin receptor in smooth muscle
6) Confidence 0.78 Published 2009 Journal Neurogastroenterol. Motil. Section Title Doc Link 19309416 Disease Relevance 0 Pain Relevance 0.15
OTR was expressed on cells of both circular and longitudinal muscle of stomach.
Gene_expression (expressed) of OTR in stomach
7) Confidence 0.78 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309416 Disease Relevance 0 Pain Relevance 0.14
These results suggest that the OTR is expressed on the smooth muscle of the stomach and mediates excitatory effect of OT on gastric motility.
Gene_expression (expressed) of OTR in smooth muscle
8) Confidence 0.78 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309416 Disease Relevance 0 Pain Relevance 0.21
These findings suggest that CSE directly increases the contractile sensitivity of preterm myometrium in response to OT by upregulating the expression of OTR mRNA and thereby increases the risk of preterm delivery in women, who smoke during pregnancy.
Gene_expression (expression) of OTR mRNA in myometrium associated with premature birth
9) Confidence 0.77 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.15 Pain Relevance 0
Similarly, in preterm myometrial strips, the expression levels of human OTR mRNA in the CSE (10(-7) pieces/ml) group were significantly higher than in the control group (P < 0.05).
Gene_expression (expression) of OTR mRNA
10) Confidence 0.77 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.29 Pain Relevance 0.06
The expression levels of rat OTR mRNA in the CSE (10(-7) pieces/ml) group were significantly higher than in the control group (P < 0.01).
Gene_expression (expression) of OTR mRNA
11) Confidence 0.77 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.32 Pain Relevance 0.07
We investigated the level of uterine OTR mRNA expression after the administration of Beta(2)-AR agonists fenoterol and hexoprenaline to rats from day 18 to 22 of pregnancy, and also tested the effect of fenoterol on uterine explants.
Gene_expression (expression) of OTR mRNA in uterine associated with agonist
12) Confidence 0.77 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.09
It was concluded that the enhanced expression of OTR mRNA induced by Beta(2)-agonists in the late-pregnant rat uterus may be a possible drawback to effective therapy of preterm uterine contractions with Beta(2)-agonists.
Gene_expression (expression) of OTR mRNA in uterine associated with dismenorea and agonist
13) Confidence 0.77 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0.10 Pain Relevance 0.27
Compound 1 competitively inhibits binding of [3H]oxytocin and the peptide antagonist 125I-ornithine vasotocin analog to human and rat oxytocin receptor expressed in human embryonic kidney 293-EBNA or Chinese hamster ovary cells with nanomolar potency.
Gene_expression (expressed) of oxytocin receptor in ovary associated with antagonist and potency
14) Confidence 0.72 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660315 Disease Relevance 0 Pain Relevance 0.22
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Gene_expression (synthesis) of OTR in smooth muscle cells associated with antagonist
15) Confidence 0.68 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
Beta 2-agonist treatment enhances uterine oxytocin receptor mRNA expression in pregnant rats.
Gene_expression (expression) of uterine oxytocin receptor mRNA in uterine associated with agonist
16) Confidence 0.67 Published 2004 Journal Mol. Reprod. Dev. Section Title Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.22
Furthermore, the expression levels of oxytocin receptor (OTR) mRNA in the myometrial strips were investigated by real-time PCR.
Spec (investigated) Gene_expression (expression) of oxytocin receptor
17) Confidence 0.67 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.39 Pain Relevance 0.08
Furthermore, the expression levels of oxytocin receptor (OTR) mRNA in the myometrial strips were investigated by real-time PCR.
Spec (investigated) Gene_expression (expression) of OTR
18) Confidence 0.67 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.39 Pain Relevance 0.08
RT-PCR method was used to observe the oxytocin receptor (OTR) and vasopressin receptor (VPR) mRNA expressions in the uterus in each group.
Gene_expression (expressions) of OTR in uterus
19) Confidence 0.59 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0.08 Pain Relevance 0
RT-PCR method was used to observe the oxytocin receptor (OTR) and vasopressin receptor (VPR) mRNA expressions in the uterus in each group.
Gene_expression (expressions) of oxytocin receptor in uterus
20) Confidence 0.59 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox