INT78050

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.63
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
plasma 2
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory marker 7 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 7 100.00 Very High Very High Very High
withdrawal 7 98.80 Very High Very High Very High
Angina 5 97.08 Very High Very High Very High
Pain 1 95.64 Very High Very High Very High
antagonist 3 87.84 High High
Etanercept 1 87.04 High High
aspirin 9 83.40 Quite High
Inflammation 21 46.32 Quite Low
tolerance 1 15.12 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 100.00 Very High Very High Very High
Myocardial Infarction 18 100.00 Very High Very High Very High
Adhesions 3 100.00 Very High Very High Very High
Obstructive Sleep Apnea 163 99.28 Very High Very High Very High
Cv General 3 Under Development 2 97.08 Very High Very High Very High
Angina 1 96.12 Very High Very High Very High
Pain 1 95.64 Very High Very High Very High
Peripheral Arterial Disease 3 94.40 High High
Metabolic Syndrome 9 93.08 High High
Thrombosis 5 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased P-selectin activity in AMI appeared to be attenuated by direct PTCA, but augmented by thrombolysis, possibly due to direct stimulatory effects of TPA on P-selectin expression.
Spec (possibly) Positive_regulation (augmented) of Positive_regulation (Increased) of P-selectin associated with myocardial infarction and percutaneous transluminal coronary angioplasty
1) Confidence 0.43 Published 1998 Journal Angiology Section Abstract Doc Link 9783645 Disease Relevance 0.95 Pain Relevance 0.50
Changes in inflammatory markers such as sCD40L, soluble P-selectin and hsCRP over 4 weeks after withdrawal of clopidogrel are shown in Table 3 (medians and interquartile ranges) and as mean percentage changes from baseline levels obtained at 12 months after clopidogrel administration.
Positive_regulation (Changes) of Positive_regulation (soluble) of P-selectin associated with inflammatory marker and withdrawal
2) Confidence 0.08 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.78 Pain Relevance 0.33
Robinson et al (2004) have demonstrated increased plasma levels of activated coagulation factors XIIa (a marker of endothelial activation or dysfunction) and VIIa, thrombin-antithrombin complex (a marker of thrombin turnover) and soluble P-selectin in subjects with OSA compared with unmatched controls, although the levels did not fall following one month of therapeutic CPAP suggesting that confounding factors such as obesity may be involved.
Positive_regulation (increased) of Positive_regulation (activated) of P-selectin in plasma associated with metabolic syndrome and obstructive sleep apnea
3) Confidence 0.05 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.03 Pain Relevance 0.09
Serum levels of E-selectin, P-selectin, L-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-I (VCAM-1) were measured at rest and after the performance of a treadmill walking test (treadmill speed 3.5 km h(-1), inclination 12%) in the untreated condition, and again after treatment with LPC.
Positive_regulation (measured) of Positive_regulation (levels) of P-selectin associated with adhesions
4) Confidence 0.02 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11592865 Disease Relevance 0.86 Pain Relevance 0.10

General Comments

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