INT78057

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 140
Total Number 141
Disease Relevance 67.75
Pain Relevance 21.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 8
microglia 6
monocyte 4
astrocytes 3
lung 3
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2379 100.00 Very High Very High Very High
cytokine 1645 100.00 Very High Very High Very High
Dopamine 301 100.00 Very High Very High Very High
adenocard 251 100.00 Very High Very High Very High
Inflammatory mediators 171 100.00 Very High Very High Very High
midbrain 61 100.00 Very High Very High Very High
agonist 175 99.82 Very High Very High Very High
alcohol 54 99.80 Very High Very High Very High
Endep 32 99.56 Very High Very High Very High
chemokine 364 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2827 100.00 Very High Very High Very High
Pulmonary Disease 1348 100.00 Very High Very High Very High
Sepsis 987 100.00 Very High Very High Very High
Injury 451 100.00 Very High Very High Very High
Bacterial Infection 75 100.00 Very High Very High Very High
Pseudomonas Infection 60 100.00 Very High Very High Very High
Shock 49 100.00 Very High Very High Very High
Cancer 478 99.84 Very High Very High Very High
Fetal Resorption 2 99.64 Very High Very High Very High
Necrosis 140 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with the concept of an increase in local TLR4 expression, immunostaining demonstrated the localization of TLR4 in infiltrating macrophages in ruptured plaque material occluding the culprit coronary artery.
Localization (localization) of TLR4 in macrophages
1) Confidence 0.77 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.90 Pain Relevance 0.03
In solid plaque material removed from the site of the ruptured plaque, staining for TLR4 was localized in infiltrating macrophages (Figure 3A) and was positive in all solid plaque samples.
Localization (localized) of TLR4 in plaque
2) Confidence 0.77 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.15 Pain Relevance 0
At 8 hr after thermal injury, lung was harvested for TLR4 mRNA assay, intestinal mucosa was harvested for TLR4 mRNA assay, and peritoneal cells were harvested from the abdominal cavity for bacterial killing activity and TLR4 as well as TNF?
Localization (harvested) of TLR4 in cavity associated with injury
3) Confidence 0.75 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.41 Pain Relevance 0.04
The rise of TLR4, TNF-?
Localization (rise) of TLR4
4) Confidence 0.72 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.69 Pain Relevance 0.39
Asea et al. [28] have reported that the release of HSP70, as a common endogenous ligand of both TLR2 and TLR4, in response to ischaemic myocardium may activate TLR2 and TLR4 signalling in circulating monocytes.
Localization (ligand) of TLR4 in myocardium
5) Confidence 0.72 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.25 Pain Relevance 0.06
Immunohistochemistry for TLR2 and TLR4
Localization (Immunohistochemistry) of TLR4
6) Confidence 0.72 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.14 Pain Relevance 0
We observed IR-induced loss of retinal neurons in both WT and Tlr4 KO retinas.
Localization (retinas) of Tlr4 in retinas
7) Confidence 0.71 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.75 Pain Relevance 0.18
TLR2 and TLR4 immunostaining is frequently co-localized with NF-?
Localization (localized) of TLR4
8) Confidence 0.68 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.92 Pain Relevance 0.25
We observed that treatment with the PS-341 significantly decreased Pa-LPS induced IL1-?
Localization (decreased) of Pa-LPS associated with pseudomonas infection
9) Confidence 0.67 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.61 Pain Relevance 0.17
Tlr4 expression and localization in the retina has been extensively studied and reported [14–20].
Localization (localization) of Tlr4 in retina
10) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 1.37 Pain Relevance 0.47
TLR4 ligand decreased thermal injury-induced bacterial translocation
Localization (translocation) of TLR4 associated with injury
11) Confidence 0.65 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.13 Pain Relevance 0
We found that LPS significantly increased the concentrations of TLR-4, NF-kappaB and MAPKs, including extracellular regulated kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAPK, in activated macrophages.
Localization (concentrations) of TLR-4 in macrophages
12) Confidence 0.65 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0.13 Pain Relevance 0.38
This possibility is supported by the lack of an effect of (s)CD14 on LIX release after high dose LPS administration, considering that respiratory epithelial cells are important for both PMN influx and LIX secretion [20], [24].
Localization (secretion) of LPS in respiratory
13) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.30 Pain Relevance 0.15
LPS administration in mice has been shown to increase watery secretions in the bowel and induce diarrhea [17,18], either of which would potentially confound our fecal output measurements.
Localization (secretions) of LPS in bowel associated with diarrhoea
14) Confidence 0.63 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1177942 Disease Relevance 0.71 Pain Relevance 0.05
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
Neg (not) Localization (present) of TLR4 in oligodendrocytes
15) Confidence 0.63 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.29 Pain Relevance 0.18
The LPS-CD14 complex, together with other adaptor proteins, binds to the toll-like receptor 4 (TLR4), which is present on microglia, but not on astrocytes, oligodendrocytes or cortical neurons [20].
Neg (not) Localization (present) of toll-like receptor 4 in oligodendrocytes
16) Confidence 0.63 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.29 Pain Relevance 0.18
As our selection of candidate genes relied on a potential protective role, we screened genes based on their natural regulation in presence of an intact LPS and GR signaling.
Localization (presence) of LPS
17) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.28 Pain Relevance 0.03
The secretion of inflammatory mediators in response to LPS supports previous observations in murine endometrial epithelial cells [11], [15].
Localization (secretion) of LPS in epithelial cells associated with inflammatory mediators
18) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.62 Pain Relevance 0.16
Except for R-LPS-induced TNF release, S-LPS and R-LPS at low dose induced acute lung inflammation in a CD14-dependent manner, while the inflammatory response triggered by high dose S-LPS or R-LPS was diminished by CD14.



Localization (release) of LPS in lung associated with inflammatory response, inflammation and pneumonia
19) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2855719 Disease Relevance 0.71 Pain Relevance 0.29
The purified 48-kDa protein enhanced LPS-induced TNF secretion by alveolar macrophages in vitro (data not shown).
Localization (secretion) of LPS in alveolar macrophages
20) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0 Pain Relevance 0.04

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